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Frontiers in Medical Science Research, 2023, 5(6); doi: 10.25236/FMSR.2023.050603.

Global research trends in bone mineral density in children with diabetes: a bibliometric and visualization study


Yuan Jianhua1, Feng Xiaoyan2, Jiang Jiemei2, Wu Pingping1, Shen Long2

Corresponding Author:
Yuan Jianhua

1Department of Pediatrics, Peace Hospital Affiliated to Changzhi Medical College, Changzhi, 046000, China

2Office of Graduate Studies, Changzhi Medical College, Changzhi, 046000, China


Research on bone density in children with diabetes has attracted increasing attention, and this study aims to investigate the global status and trends in this field.From the Web of Science's Science Citation Index, research papers related to bone density in children with diabetes from 1984-2022 were retrieved. Source data were studied and indexed using bibliometric methods. The visualization study used VOS viewer software for literature coupling, co-authorship, co-citation and co-occurrence analysis to analyze the publication trend of bone density in children with diabetes.A total of 1074 articles were included. Globally, the number of related research interests and publications is increasing every year. The United States contributes the most to global research, receives the most citations, and has the highest h-index. The Journal of Clinical Endocrinology and Metabolism has the highest number of publications.The university of pennsylvania,Childrens hospital of philadelphia,Pennsylvania medicine,Harvard university and university of Sydney are the largest contributors. Research can be divided into four categories: mechanistic research, animal research, clinical trials, and tissue engineering. Mechanism research is expected to be the next hot topic in this field.From the current global research trend, the number of papers on bone density in children with diabetes will continue to increase. The United States is the largest contributor in this area. Much of the effort is devoted to the mechanisms of changes in bone density in children with diabetes, which could be the next hot spot in research.


Diabetes mellitus in children; Bone mineral density; Global trends; Bibliometrics; Visualization research

Cite This Paper

Yuan Jianhua, Feng Xiaoyan, Jiang Jiemei, Wu Pingping, Shen Long. Global research trends in bone mineral density in children with diabetes: a bibliometric and visualization study. Frontiers in Medical Science Research (2023) Vol. 5, Issue 6: 12-19. https://doi.org/10.25236/FMSR.2023.050603.


[1] Hou L, Li X, Liu L, et al. A Multicenter Survey of Type I Diabetes Mellitus in Chinese Children. Front Endocrinol. 2021;12:583114. doi:10.3389/fendo.2021.583114

[2] Donat A, Knapstein PR, Jiang S, et al. Glucose Metabolism in Osteoblasts in Healthy and Pathophysiological Conditions. IJMS. 2021;22(8):4120. doi:10.3390/ijms22084120

[3] Cipriani C, Colangelo L, Santori R, et al. The Interplay Between Bone and Glucose Metabolism. Front Endocrinol. 2020;11:122. doi:10.3389/fendo.2020.00122

[4] Di Iorgi N, Maruca K, Patti G, Mora S. Update on bone density measurements and their interpretation in children and adolescents. Best Pract Res Clin Endocrinol Metab. 2018;32(4):477-498. doi:10.1016/j.beem.2018.06.002

[5] Ikle JM, Gloyn AL. 100 YEARS OF INSULIN: A brief history of diabetes genetics: insights for pancreatic beta-cell development and function. Journal of Endocrinology. 2021;250(3):R23-R35. doi:10.1530/JOE-21-0067

[6] Rosen ED, Kaestner KH, Natarajan R, et al. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018;67(10):1923-1931. doi:10.2337/db18-0537

[7] Ninkov A, Frank JR, Maggio LA. Bibliometrics: Methods for studying academic publishing. Perspect Med Educ. 2021;11(3):173-176. doi:10.1007/S40037-021-00695-4

[8] Sanyoura M, Philipson LH, Naylor R. Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options. Curr Diab Rep. 2018;18(8):58. doi: 10.1007 /s11892-018-1024-2

[9] Ali MJ. Forewarned Is Forearmed: The h-Index as a Scientometric. Semin Ophthalmol. 2021;36(1-2):1. doi:10.1080/08820538.2021.1894889

[10] Schober P, Vetter TR. Logistic Regression in Medical Research. Anesth Analg. 2021;132(2):365-366. doi:10.1213/ANE.0000000000005247

[11] Casey F, Negi S, Zhu J, et al. OmicsView: Omics data analysis through interactive visual analytics. Comput Struct Biotechnol J. 2022;20:1277-1285. doi:10.1016/j.csbj.2022.02.022

[12] Engoren M, Pancaro C, Yeldo NS, Kerzabi LS, Douville N. Comparison of static and rolling logistic regression models on predicting invasive mechanical ventilation or death from COVID-19-A retrospective, multicentre study. Clin Respir J. 2023; 17(1):40-49. doi: 10.1111/ crj.13560

[13] Predieri B, Bruzzi P, Bigi E, et al. Endocrine Disrupting Chemicals and Type 1 Diabetes. Int J Mol Sci. 2020;21(8):2937. doi:10.3390/ijms21082937

[14] Bernasconi S. Management of the main endocrine and diabetic disorders in children. Minerva Pediatr. 2020;72(4). doi:10.23736/S0026-4946.20.05990-3

[15] Albert Pérez E, Mateu Olivares V, Martínez-Espinosa R, Molina Vila M, Reig García-Galbis M. New Insights about How to Make an Intervention in Children and Adolescents with Metabolic Syndrome: Diet, Exercise vs. Changes in Body Composition. A Systematic Review of RCT. Nutrients. 2018; 10(7):878. doi:10.3390/nu10070878

[16] MacPherson M, Cranston K, Locke S, Vis-Dunbar M, Jung ME. Diet and exercise interventions for individuals at risk for type 2 diabetes: a scoping review protocol. BMJ Open. 2020;10(11):e039532. doi:10.1136/bmjopen-2020-039532

[17] Heap J, Murray MA, Miller SC, Jalili T, Moyer-Mileur LJ. Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus. The Journal of Pediatrics. 2004;144(1):56-62. doi:10.1016/j.jpeds.2003.10.066

[18] Valerio G, Del Puente A, Esposito-del Puente A, Buono P, Mozzillo E, Franzese A. The Lumbar Bone Mineral Density Is Affected by Long-Term Poor Metabolic Control in Adolescents with Type 1 Diabetes mellitus. Horm Res Paediatr. 2002;58(6):266-272. doi:10.1159/000066441

[19] Moyer-Mileur LJ, Dixon SB, Quick JL, Askew EW, Murray MA. Bone mineral acquisition in adolescents with type 1 diabetes. The Journal of Pediatrics. 2004;145(5):662-669. doi:10. 1016/j.jpeds.2004.06.070

[20] Gunczler P, Lanes R, Paoli M, Martinis R, Villaroel O, Weisinger JR. Decreased Bone Mineral Density and Bone Formation Markers Shortly After Diagnosis of Clinical Type 1 Diabetes Mellitus. Journal of Pediatric Endocrinology and Metabolism. 2001;14(5). doi:10.1515/JPEM.2001.14.5.525

[21] De Schepper J, Smitz J, Rosseneu S, Bollen P, Louis O. Lumbar Spine Bone Mineral Density in Diabetic Children with Recent Onset. Horm Res Paediatr. 1998;50(4):193-196. doi:10.1159/000023273

[22] Wu H, Patterson CC, Zhang X, et al. Worldwide estimates of incidence of type 2 diabetes in children and adolescents in 2021. Diabetes Res Clin Pract. 2022;185:109785. doi: 10.1016/ j.diabres. 2022.109785

[23] Patterson CC, Karuranga S, Salpea P, et al. Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107842. doi:10. 1016/j.diabres.2019.107842

[24] Bilinski WJ, Paradowski PT, Sypniewska G. Bone health and hyperglycemia in pediatric populations. Crit Rev Clin Lab Sci. 2020;57(7):444-457. doi:10.1080/10408363.2020.1739619

[25] Kindler JM, Gallo S, Khoury PR, Urbina EM, Zemel BS. Diet Quality and Bone Density in Youth with Healthy Weight, Obesity, and Type 2 Diabetes. Nutrients. 2021;13(9):3288. doi:10. 3390/nu 13093288

[26] Calò LN. Impact metrics and science evaluation. Rev Peru Med Exp Salud Publica. 2022; 39(2):236-240. doi:10.17843/rpmesp.2022.392.11171

[27] Yip W, Fu H, Chen AT, et al. 10 years of health-care reform in China: progress and gaps in Universal Health Coverage. Lancet. 2019;394(10204):1192-1204. doi: 10.1016/ S0140-6736 (19)321 36-1

[28] Chen P, Wang D, Shen H, et al. Physical activity and health in Chinese children and adolescents: expert consensus statement (2020). Br J Sports Med. 2020;54(22):1321-1331. doi:10.1136/ bjsports- 2020-102261

[29] Guo H, Shen Z, Zeng J, Hong N. Hybrid Methods of Bibliographic Coupling and Text Similarity Measurement for Biomedical Paper Recommendation. Stud Health Technol Inform. 2022;290:287-291. doi:10.3233/SHTI220080

[30] Ciancia S, van Rijn RR, Högler W, et al. Osteoporosis in children and adolescents: when to suspect and how to diagnose it. Eur J Pediatr. 2022;181(7):2549-2561. doi: 10.1007/ s00431-022-04455-2