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Frontiers in Medical Science Research, 2023, 5(7); doi: 10.25236/FMSR.2023.050705.

Research Progress on Post Stroke Depression and 5-HTTLPR Methylation


Yiming Jiang1, Huikai Wang2, Jian Sun3, Xinchen Ren3

Corresponding Author:
Huikai Wang

1Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China

2Binzhou Hospital of Traditional Chinese Medicine (Binzhou Medical University TCM Hospital), Binzhou, China

3Binzhou Medical University Hospital, Binzhou, Shandong, China


The emergence of PSD can lead to adverse emotional experiences for patients and also affect rehabilitation outcomes. Due to the relatively hidden occurrence of post stroke depression and the presence of post stroke language disorders in some patients, the treatment of post stroke depression is more difficult. The lower concentration of 5-HT in the intercellular space of the brain is associated with depression. The raphe nuclei contains serotonergic neurons whose main function is to produce 5-HT. The activation of serotonin neurons has an inhibitory effect on depression. For patients with post-stroke depression, the combination of acupuncture and medical treatment can effectively reduce the incidence of post-stroke depression on the basis of traditional treatment methods. With the establishment of the "biological psychological social" medical model, the mechanism of post stroke depression has begun to be addressed through humanized thinking. Pay more attention to the quality of life of patients with post-stroke depression. It is particularly important to seek more systematic treatment for post-stroke depression. Therefore, it is necessary to study the treatment mechanism of post stroke depression (PSD).


post stroke depression, 5-HTTLPR, methylation

Cite This Paper

Yiming Jiang, Huikai Wang, Jian Sun, Xinchen Ren. Research Progress on Post Stroke Depression and 5-HTTLPR Methylation. Frontiers in Medical Science Research (2023) Vol. 5, Issue 7: 29-33. https://doi.org/10.25236/FMSR.2023.050705.


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