Wang Jiale1, Zhao Yinglin2, Yang Yurong1, Jiang Wentao1, Zhang Shuwen1
1Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
2Xi'an Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi, 710001, China
This paper reviews traditional Chinese medicine's research progress in preventing and treating knee osteoarthritis according to the domestic literature in recent years. The main contents of the research are collated, analyzed, and summarized. The results show that traditional Chinese medicine for the treatment of knee osteoarthritis includes single medicine, compound medicine, acupuncture, and drug combination, which can affect related molecules in experiments or clinical and achieve the purpose of treating knee osteoarthritis. Many conclusions are drawn from the research. Traditional Chinese medicine can affect the occurrence, development, and outcome of knee osteoarthritis at the molecular and cellular levels through multiple forms and multiple targets to achieve the treatment's purpose.
TCM treatment; Knee osteoarthritis; Research progress
Wang Jiale, Zhao Yinglin, Yang Yurong, Jiang Wentao, Zhang Shuwen. Research Progress in the Treatment of Knee Osteoarthritis with Chinese Medicine. Frontiers in Medical Science Research (2023) Vol. 5, Issue 9: 37-41. https://doi.org/10.25236/FMSR.2023.050907.
 Joint Surgery Group, Orthopaedic Branch, Chinese Medical Association, Osteoarthritis Group, Orthopedic Surgeons Branch, Chinese Medical Doctor Association, National Clinical Medical Research Center for Geriatric Diseases (Xiangya Hospital), et all. Chinese guideline for diagnosis and treatment of osteoarthritis (2021 edition). Chinese Journal of Orthopaedics, 2021, 41(18):1291-1314.
 Zhao Xiaoming, Zhang Yingang, Li Yanyan. Progress in stepwise treatment of knee osteoarthritis [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2021, 30(30): 3410-3415.
 Sun Zhitao, Feng Hualong, He Shengli, et al. Pilose antler regulates the expression of ADAMTS-4/TIMP-3 gene in the extracellular matrix in a rabbit model of osteoarthritis [J]. Chinese Journal of Tissue Engineering Research, 2018, 22(32): 5133-5138.
 Hong Zhenqiang, Gao Hongjian, Su Youxin, et al. Effect of Total Alkaloids fromSemen Strychni on Cartilage Injury in Rabbit Model of Knee Osteoarthritis and It′s Mechanisms [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2018, 38(08): 991-996.
 Zhong Huan, Pei Xin, Zhou Yujing, et al. Effect of asarum on local inflammatory factors in different tissues of knee osteoarthritis in rabbits [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2021, 41(12): 1496-1501.
 Wang Caiwei, Yu Lingying, Yan Li, et al. Study on the Effect of Agkistrodon Aqueous Extract on Pain Model of Osteoarthritis in Rats [J]. Chinese Journal of Modern Applied Pharmacy, 2019, 36(03): 292-296.
 Li Yuan, Peng Liping, Yu Tian, et al. Effects of Liuwei Gubi Decoction on Synovial Tissues in Rabbits with Osteoarthritis and Correlation with Cartilage Repair [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2019, 36(5): 702-707.
 Liu Yang, Sun Quan, Yang Di, et al. Effect of Yougui Pill on TGF-β 1/Smads signaling pathway in rats with osteoarthritis [J]. Chinese Journal of Osteoporosis, 2021, 27(10): 1419-1424.
 Lin Huajie, Jin Yong, Jia Jinrong, et al. Clinical Study on Duhuo Jisheng Tang for Knee Osteoarthritis [J]. Journal of New Chinese Medicine, 2020, 52(01): 34-36.
 Wang Yanzhi, Wu Zhijia, Zhang Haiyan, et al. Effect of Duhuo Zizhi Decoction on knee osteoarthritis based on Zinc/ZIP8 signaling pathway [J]. Lishizhen Medicine and Materia Medica Research, 2020, 31(05): 1057-1060.
 Wang Bo, Yang Guangyu. Clinical observation on warming acupuncture and moxibustion with Qiang Fang Qubi Decoction in the treatment of knee osteoarthritis of type of cold-dampness impediment obstruction [J]. Modern Journal of Integrated Traditional Chinese and Western, 2021, 30(04): 348-352+359.
 Chen Jinshen, Zhang Jianhua. Clinical observation on treatment of knee osteoarthritis with combination of acupuncture and medicine [J]. Shanxi Journal of Traditional Chinese Medicine, 2021, 37(09): 39-40.
 Liang Zexu, Gao Xi. Clinical Observation on Knee Osteoarthritis Treated by Wrist-ankle Acupuncture Combined with Guizhi Shaoyao Zhimu Decoction [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2021, 23(11): 192-196.
 Li Bingjie, Feng Shulan, Long Hua, et al. Clinical Observation of Tendon Moxibustion Combined with Duhuo Jisheng Decoction for Treatment of Knee Osteoarthritis of Obstructive Syndrome Due to Wind, Cold and Dampness [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2020, 37(07): 1316-1320.
 Pan Jianke, Yang Weiyi, Liu Jun, et all. Effect of Longbie Capsule on Pathologic Changes of Cartilage and Synovium of Knee Osteoarthritis Rats[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2017, 37(07):807-812.
 Lu Sumei, Zhang Ruili. Epidemiological research progress of knee osteoarthritis in middle-aged and elderly [J]. Chinese Journal of Gerontology, 2016, 36(16):4133-4135.
 Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis [J]. Nature reviews. Rheumatology, 2014, 10(7): 437-441.