Welcome to Francis Academic Press

Frontiers in Medical Science Research, 2023, 5(9); doi: 10.25236/FMSR.2023.050919.

Electroacupuncture Combined with Acupoint Catgut Embedding for Treating Paediatric Epilepsy: A Case Report


Kun Wang1, Gaiqin Yang2, Haichen Gao1, Wanyi Ao1, Yao Lu1

Corresponding Author:
Gaiqin Yang

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, China


Paediatric epilepsy is a common neurological disorder, and this case report describes the good efficacy of electroacupuncture combined with acupuncture burrowing in the treatment of paediatric epilepsy. In this case report, an adolescent patient was diagnosed with paediatric epilepsy and had had recurrent seizures for many years, seriously affecting his daily life, with poor results from oral medication and frequent seizures. However, after 2 months of electroacupuncture combined with acupoint catgut-embedding, the seizure frequency was significantly reduced or even eliminated. With this case report, electroacupuncture combined with acupoint catgut-embedding can be used as a novel alternative therapy for paediatric epilepsy.


Electroacupuncture; acupoint catgut-embedding; paediatric epilepsy; case report

Cite This Paper

Kun Wang, Gaiqin Yang, Haichen Gao, Wanyi Ao, Yao Lu. Electroacupuncture Combined with Acupoint Catgut Embedding for Treating Paediatric Epilepsy: A Case Report. Frontiers in Medical Science Research (2023) Vol. 5, Issue 9: 112-119. https://doi.org/10.25236/FMSR.2023.050919.


[1] Solomon L Moshé, Perucca E, Ryvlin P, et al. Epilepsy: new advances [J]. Elsevier, 2015, 385 (9971): 884-898. 

[2] Tulli Eleonora, Di Cara Giuseppe, Iapadre Giulia, et al. An update on brivaracetam for the treatment of pediatric partial epilepsy [J]. Expert opinion on pharmacotherapy, 2021, 22(11): 1387-1395. 

[3] Chan See Wai, Dervan Leslie A, Watson R Scott, et al. Epilepsy duration is an independent factor for electrocardiographic changes in pediatric epilepsy [J]. Epilepsia open, 2021, 6(3):588-596. 

[4] Roland D Thijs, Rainer Surges, Terence J O'Brien, et al. Epilepsy in adults [J]. The Lancet, 2019, 393(10172):689-701. 

[5] Fisher Robert S, Acevedo Carlos, Arzimanoglou Alexis, et al. ILAE official report: a practical clinical definition of epilepsy [J]. Epilepsia, 2014, 55(4):475-482. 

[6] Fisher Robert S. The New Classification of Seizures by the International League against Epilepsy 2017 [J]. Current neurology and neuroscience reports, 2017, 17(6):48. 

[7] Yang Xiujuan. Case of epilepsy after cerebral hemorrhage caused by traumatism [J]. Chinese Acupuncture & Moxibustion, 2016, 36(5):560. 

[8] Sánchez Fernández Iván, Loddenkemper Tobias. Subunit composition of neurotransmitter receptors in the immature and in the epileptic brain [J]. BioMed research international, 2014, 2014:301950. 

[9] N.C. Danbolt, D. N. Furness, Y. Zhou, et al. Neuronal vs glial glutamate uptake: Resolving the conundrum [J]. Neurochemistry International, 2016, 98:29-45. 

[10] Sedlak Thomas W, Paul Bindu D, Parker Gregory M, et al. The glutathione cycle shapes synaptic glutamate activity [J]. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(7):2701-2706. 

[11] Neuray Caroline, Maroofian Reza, Scala Marcello, et al. Early-infantile onset epilepsy and developmental delay caused by bi-allelic GAD1 variants [J]. Brain: a journal of neurology, 2020, 143(8):2388-2397. 

[12] Maedeh Ghasemi, Nasrin Mehranfard. Mechanisms underlying anticonvulsant and proconvulsant actions of norepinephrine [J]. Neuropharmacology, 2018, 137:297-308. 

[13] Roth Bryan L, Xia Zongqi. Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis [J]. Critical reviews in neurobiology, 2004, 16(4):229-236. 

[14] Zhan Qiong, Buchanan Gordon F, Motelow Joshua E, et al. Impaired Serotonergic Brainstem Function during and after Seizures [J]. The Journal of neuroscience: the official journal of the Society for Neuroscience, 2016, 36(9): 2711-2722. 

[15] Gigout S, Wierschke S, Dehnicke C, et al. Different pharmacology of N-desmethylclozapine at human and rat M2 and M 4 mAChRs in neocortex [J]. Naunyn-Schmiedeberg's archives of pharmacology, 2015, 388(5):487-496. 

[16] Shorvon Simon D. Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009 [J]. Epilepsia, 2009, 503(3):93-130. 

[17] Besi E, Boniface D R, Cregg R, et al. Comparison of tolerability and adverse symptoms in oxcarbazepine and carbamazepine in the treatment of trigeminal neuralgia and neuralgiform headaches using the Liverpool Adverse Events Profile (AEP) [J]. The journal of headache and pain, 2015, 16(1):563. 

[18] Sigride Thome-Souza, Kette D. Valente. Valproate and Lamotrigine in Pediatric Patients with Refractory Epilepsy: After the First Year [J]. Pediatric Neurology, 2013, 48(6):436-442. 

[19] Wang Wenzhu, Li Haigang, Yu Jintao, et al. Correction to: Protective Effects of Chinese Herbal Medicine Rhizoma drynariae in Rats after Traumatic Brain Injury and Identification of Active Compound [J]. Molecular neurobiology, 2022, 60(3):1746-1747. 

[20] Lin Chia Hui, Hsieh Ching Liang. Chinese Herbal Medicine for Treating Epilepsy [J]. Frontiers in Neuroscience, 2021, 15:682821. 

[21] Zhao Zefeng, He Xirui, Ma Cuixia, et al. Excavating Anticonvulsant Compounds from Prescriptions of Traditional Chinese Medicine in the Treatment of Epilepsy [J]. The American journal of Chinese medicine, 2018, 46(4):707-737. 

[22] Lu Haimei, Luo Mengxian, Chen Rongrong, et al. Efficacy and safety of traditional Chinese medicine for the treatment of epilepsy: A updated meta-analysis of randomized controlled trials [J]. Epilepsy Research, 2023, 189:107075. 

[23] Yu Yunhong, Xie Wei, Wang Changjun, et al. Chaihushugan decoction exerts antiepileptic effects by increasing hippocampal glutamate metabolism in pentylenetetrazole-kindled rats [J]. Journal of Traditional Chinese Medicine, 2015, 35(6):659-665. 

[24] Yang Baowang, Wang Jing, Zhang Ni, et al. Effect of Nobiletin on Experimental Model of Epilepsy [J]. Translational neuroscience, 2018, 9(1):211-219. 

[25] Zhao Chenyang, Lu Lu, Liu Wenyu, et al. Complementary and alternative medicine for treating epilepsy in China: A systematic review [J]. Acta neurologica Scandinavica, 2022, 146(6):775-785. 

[26] Zhang Xuanping, Jia Chunsheng, Wang Jianling, et al. Acupoint catgut-embedding therapy: superiorities and principles of application [J]. Chinese Acupuncture & Moxibustion, 2012, 32(10): 947-951. 

[27] Wu J, Fu Q, Yang S, et al. Efficacy and Safety of Acupoint Catgut Embedding for Diarrhea- Predominant Irritable Bowel Syndrome and Constipation-Predominant Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis [J]. Evidence-based complementary and alternative medicine: eCAM, 2020, 2020:5812320. 

[28] Guo Mao, Le Xie, Qinyu Wang, et al. Effectiveness and Safety of Acupoint Catgut Embedding for the Treatment of Poststroke Constipation: A Systematic Review and Meta-Analysis [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022:8080297. 

[29] Chen Teng, Zhang Wenwen, Chu Yuxia, et al. Acupuncture for Pain Management: Molecular Mechanisms of Action [J]. The American journal of Chinese medicine, 2020, 48(4):793-811. 

[30] Wang Xiaoling, Lin Guohua, Xu Nuo, et al. Analysis of adverse reactions of acupoint catgut embedding therapy [J]. Chinese Acupuncture & Moxibustion, 2020, 40(2):193-196. 

[31] Huang Jiajia, Liang Junquan, Xu Xiaokang, et al. Safety of Thread Embedding Acupuncture Therapy: A Systematic Review [J]. Chinese Journal of Integrative Medicine, 2021, 27(12):1-9. 

[32] Oliveira Gilvano Amorim, Tedrus Gloria M.A.S., Nucci Luciana Bertoldi, et al. Acupuncture, seizure frequency, and quality of life in temporal lobe epilepsy [J]. Epilepsy & Behavior, 2021, 122: 108213. 

[33] Deng Bowen, Luo Xiaozhou, Tang Chunzhi, et al. A Meta-analysis of the Effectiveness of Acupuncture in the Treatment of Epilepsy [J]. Acupuncture Research, 2018, 43(4):263-268. 

[34] Xu Zhijie, Wu Linna, Xu Fan, et al. Acupoint selection rules of acupuncture and moxibustion for post-stroke epilepsy based on data miningtechnology [J]. Chinese Acupuncture & Moxibustion, 2023, 43(6):715-720. 

[35] Gao Dongsheng, Ma Linqing, Xie Yunliang, et al. Electroacupuncture Promotes Autophagy by Regulating the AKT/mTOR Signaling Pathway in Temporal Lobe Epilepsy [J]. Neurochemical research, 2022, 47(8):2396-2404. 

[36] Mao Zhongnan, Gao Zhiguo, Zhang Guangwu, et al. Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type [J]. Chinese Acupuncture & Moxibustion, 2011, 31(6):509-512.