Teichoic acids (TAs) are one of the key virulence factors of S. pneumoniae, as well as one of the key components of the bacterial cell wall. The complexity of TAs structure and biosynthesis stems from its diverse functions and roles, including their involvement in the regulation of bacterial virulence and bacterial division, it also plays a crucial role in bacterial transformation. In this paper, the basic structure and biosynthesis of teichoic acid in S. pneumoniae were described. Meanwhile, the functions of TAs in the pathogenic mechanism of S. pneumoniae, the regulatory factors of biosynthesis, and the effects in vaccines are summarized. Finally, we also provide a perspective for future research. This review may provide a foundation for further studies to provide the pathogenic mechanism of TAs in S. pneumoniae and a theoretical basis for the design of vaccines.

Miao Yao, Yumeng Hu, Jiali Chen, Kaifeng Wu. Streptococcus Pneumoniae Teichoic Acids. Frontiers in Medical Science Research (2024), Vol. 6, Issue 2: 1-9. https://doi.org/10.25236/FMSR.2024.060201.

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