Frontiers in Medical Science Research, 2024, 6(2); doi: 10.25236/FMSR.2024.060220.
Shuangxi Wang1, Renqing Zeng2, Xianfa Liu2
1First College of Clinical Medicine, Gannan Medical University, Ganzhou, Jiangxi, China
2Emergency Department (Trauma Center), The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, including ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina (UA). Currently, the clinical diagnosis of ACS relies on three key factors: clinical data (such as medical history, age, symptoms, etc.), electrocardiogram (ECG), and cardiac biomarkers (cTn, MyO, CK-MB, NT-proBNP, etc.). However, diagnosing UA patients and some NSTEMI patients can be challenging due to the absence of characteristic electrocardiogram dynamic evolution seen in STEMI patients. This is particularly true in cases with mild symptoms or no obvious chest pain and negative detection of myocardial injury markers. Recent studies have highlighted the potential clinical value and availability of growth differentiation factor 15 (GDF-15) as a new cardiac biomarker closely associated with the occurrence and prognosis of ACS [1]. However, further investigation is needed to fully understand its role in ACS. This article aims to review the clinical application value of GDF-15 in acute coronary syndrome.
Acute Coronary Syndrome (ACS), Growth Differentiation Factor-15 (GDF-15), Early Diagnosis, Prognostic Evaluation, Clinical Treatment
Shuangxi Wang, Renqing Zeng, Xianfa Liu. Research Status of Growth Differentation Factor-15 in Acute Coronary Syndrome. Frontiers in Medical Science Research (2024), Vol. 6, Issue 2: 133-139. https://doi.org/10.25236/FMSR.2024.060220.
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