In recent years, female mammary gland hyperplasia appears in the young age, and many adolescent women will also have symptoms of mammary gland hyperplasia. Acupuncture treatment of mammary gland hyperplasia not only has significant effects, but also has obvious therapeutic advantages with fewer side effects, low pain and no scar. The purpose of this study is to prove that traditional chinese medicine acupuncture can reduce breast pain in patients with mammary gland hyperplasia, reduce the volume of breast lumps, and improve the quality of life of patients. In this study, we searched China Knowledge Network (CNKI), Wan Fang Database, pubmed, Cochrane Library, Google Scholar, and medicine database for studies published between January 2018 and January 2023. In addition, we also manually searched the Weip Data-base (VIP) database for studies published between January 2018 and January 2023. All randomized controlled trials (RCTs) of acupuncture in the treatment of mammary gland hyperplasia were included. Results: Of the selected 363 records, 57 were eligible and data were available from 16 randomized controlled trials, all of which had a low to moderate risk of overall bias. (16 interventions, 1232 participants) showed that the treatment group had a better effect on mammary gland hyperplasia than the control group (Risk Ratio [M-H, Fixed] 1.22, 95%CI 1.16 to 1.28, I² = 0%). Acupuncture can effectively treat breast pain in patients with mammary gland hyperplasia, reduce the size and hardness of breast lumps, and improve the patient's quality of life. In addition, acupuncture can also regulate patients' emotional changes and menstrual abnormalities. This study was pre-registered on PROSPERO under the registration number CRD42023468786.

Xuening Li, Cyrelle D. Agunod. Effectiveness of acupuncture in reducing pain and improving quality of life of patients with mammary gland hyperplasia: A meta-analysis with systematic review. Frontiers in Medical Science Research (2024), Vol. 6, Issue 3: 13-20. https://doi.org/10.25236/FMSR.2024.060303.

[1] Zhang, W.Y., Gao, Y., Lin, M.T., Huang, X.Y., & Lin P. (2021). Research status of pathogenesis and syndrome differentiation of MGH. Journal of Applied Traditional Chinese Medicine (11), 112-115. https://doi.org/10.13729/ j.issn.1671-7813.z20201608

[2] Ma, W., Jin Q.X., Wu, Y.F., & Jin, F. (2016). Expert consensus on diagnosis and treatment of breast hyperplasia. Chinese Journal of Practical Surgery (07), 759-762.

[3] Lu X. Q., Dai, L. L., Chen, L., & Zhai, D. (2022). Clinical observation of acupuncture combined with acupoint application in the treatment of mammary hyperplasia. J Zhejiang Chinese Medicine University (11), 1278-1282. https://doi.org/10.16466/ j.ssn1005-5509.2022.11.017

[4] Zhang, Y. Y. (2019). A deep stab perineum point set of the efficacy of treatment of breast cystic hyperplasia clinical studies (master's degree thesis, shanxi university of TCM). https://kns. cnki. net/ KCMS/detail/detail.aspx?dbname=CMFD202001&filena me=1019199304.nh

[5] Su, P. X. (2018). Wang's clinical observation of acupuncture point treatment of mammary gland hyperplasia (Ph.D. Dissertation, university of Chinese medicine in guangzhou). https://kns.cnki. net/KCMS/detail/detail.aspx?dbname=CDFDLAST2019&filename=10 18274019.nh

[6] Wang, Y. Y., & Wang, Y. L. (2022) Analysis on the clinical effect of acupuncture and moxibustion in treating mammary hyperplasia [J]. Health Required Reading (33), 198-199,201.  

[7] Lu, X. Q. (2018). Based on the meridian syndrome differentiation of acupuncture in the treatment of disease of mammary gland hyperplasia clinical studies (master's degree thesis, zhejiang university). https://kns.cnki.net/KCMS/detail/detail.aspx?dbname=CMFD201901&filename=10 19010296.nh

[8] Jiang, X. W. (2021). Clinical observation of acupuncture combined with medicine in treating mammary hyperplasia. Inner Mongolia Traditional Chinese Medicine (06), 95-96. doi:10.16040/j. cnki.cn 15-1101.2021.06.057.

[9] Li, T., Chen, H. F., Zhu, X. Y., Zhang, Z., Zhao, J. Q. & Liu, M. P. (2020). Feasibility study on rapid treatment of mammary hyperplasia by acupuncture at folk acupoint [J]. Longevity (8), 192,194.

[10] Si, H. J., Huang, B. J., Liu, S. Q. & Wu, H. Y. (2020). Clinical observation of Chai Xiangning Shen Decoction combined with acupuncture in the treatment of mammary hyperplasia with liver-qi stagnation. Inner Mongolia Traditional Chinese Medicine (10), 32-33. doi:10.16040/j.cnki.cn15-1101.2020.10.018.

[11] Zhao, D. (2020). Based on the meridian syndrome differentiation of acupuncture therapy for BI - RADS 3-4 patients with hyperplasia of mammary glands of clinical observation (a master's degree thesis, yunnan university of traditional Chinese medicine). https://kns.cnki.net/KCMS/ detail/detail.aspx? dbname=CMFD202 101&filename=1020086603.nh

[12] Zhong, Y. (2021) Clinical Effect of Jin Sanjin combined with Xiaojiean in the treatment of hyperplasia of mammary gland [D]. Guangdong: Guangzhou University of Traditional Chinese Medicine.

[13] Lu, X. Q., Zhai, D., Chen, F., & Zhou, R. (2021). Meridian syndrome differentiation acupuncture method of clinical observation for the treatment of disease of mammary gland hyperplasia. Journal of guangzhou university of traditional Chinese medicine (12), 2669-2674. https://doi.org/ 10.13359 / j.carol carroll nki GZXBTCM. 2021.12.021 

[14] Li, Y. P. & Ma, Y. Z. (2023). Clinical effect of Jing Luo acupuncture and moxibustion combined with Xiaotong Sanjie Decoction in the treatment of mammary hyperplasia. Shenzhen Journal of Integrated Chinese and Western Medicine (10), 51-54. doi:10.16458/j.cnki.1007-0893.2023.10.016.

[15] Wang, L. & Wu, J. (2018). Clinical analysis of Xiaojin capsule combined with acupuncture in the treatment of mammary hyperplasia. Inner Mongolia Traditional Chinese Medicine (06), 18-19. doi:10.16040/j.cnki.cn15-1101.2018.06.014.

[16] Wen, Q. F. (2021). Curative effect of acupuncture combined with Xiaopi Ruan Decoction in treating mammary hyperplasia with liver-depression spittoon. Chinese Journal of Practical Medicine (16), 158-160. (in Chinese) doi:10.14163/j.cnki.11-5547/r.2021.16.061.

[17] Ji, S. B. (2020). Acupuncture combined with Chinese medicine in the treatment of 34 cases of mammary hyperplasia [J]. Guangming Chinese Medicine (18), 2905-2907. doi:10.3969/j.issn.1003-8914.2020.18.043.

[18] Feng, C., Li, Li., Gong, F.Y. & Zhang, Q. (2021). Clinical study on the treatment of mammary hyperplasia with blood stasis and phlegm by acupuncture combined with self-made RuPi Quyu Decoction. Integrated Chinese and Western Medicine Research (01), 11-13+18. 

[19] Liu, C. N., Wu, N., Zhao, X. L. & Ma, Z. X. (2019). Clinical efficacy of acupuncture combined with TCM granules in the treatment of mammary hyperplasia. Inner Mongolia Traditional Chinese Medicine (12), 101-102. doi:10.16040/j.cnki.cn15-1101.2019.12.067.

[20] Shan, X. Y., Lai, S. T. & Li, C. Y. (2021). Clinical effect of acupuncture and moxibustion combined with Xiaobi Decoction on mammary hyperplasia. Clinical Research of Chinese Medicine (10), 40-42.

[21] Shi, J. J., Cui, M. ., Dong, W. W., Ding, R. B., Shi, L. & Wang, X. H. (2021). Analysis of clinical efficacy of Prunella tablets in the treatment of breast hyperplasia. Systems Medicine (22), 81-84. doi:10.19368/j.cnki.2096-1782.2021.22.081.

[22] Wang, Z. Y. (2020). The electric needle lacteal painful disease clinical curative effect observation (a master's degree thesis, China academy of traditional Chinese medicine). https://kns.cnki.net/ KCMS/detail/detail.aspx?dbname=CMFD202101&filename=102008 5853.nh