Frontiers in Medical Science Research, 2024, 6(3); doi: 10.25236/FMSR.2024.060308.
Yongquan Liu1, Luchang Yin2
1Respiratory Department, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, 261041, China
2Internal Medicine-Cardiovascular Department, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, 261041, China
To observe whether pre-treatment with Jiawei Yuping Fengsan granules can alleviate secondary lung injury in ischemic stroke. 30 SPF grade male SD rats were randomly divided into three groups: sham surgery group (sham group), cerebral ischemia-reperfusion group (IR group), modified Yupingfeng powder particle pretreatment cerebral ischemia-reperfusion group (Y-IR group), sham surgery group: no intervention; IR group: equal amount of physiological saline; Y-IR group; Jiawei Yuping Fengsan granules 10mg/kg. After successful modeling, ischemia lasted for 3 hours and reperfusion lasted for 2 hours. After the experiment, the total cell count and neutrophil percentage in bronchoalveolar lavage fluid (BALF) were measured; Measure oxidative stress factors (MDA, SOD) in rat lung tissue and blood; The expression level of inflammatory factors (TNF- α, IL-1β and IL-6). Compared with the IR group, the expression levels of total cell count and neutrophil percentage in bronchoalveolar lavage fluid (BALF) of rats in the Y-IR group significantly decreased, with statistical significance (P<0.05). Compared with the IR group, the expression level of MDA in lung tissue and serum of rats in the Y-IR group significantly decreased, while SOD activity significantly increased, with statistical significance (P<0.05). Compared to the IR group, in the lung tissue and serum of rats in the Y-IR group , The expression level of TNF - α, IL-1β,IL-6 content significantly decreased, and the difference was statistically significant (P<0.05). Jiawei Yuping Fengsan Granules have a protective effect on secondary lung injury caused by ischemic stroke by inhibiting neutrophil aggregation, inhibiting inflammatory response, and alleviating oxidative stress.
Jiawei Yuping Fengsan granules; Ischemic stroke with secondary lung injury; Inflammatory factors
Yongquan Liu, Luchang Yin. Jiawei Yuping Fengsan Granules Relieve Secondary Lung Injury in Ischemic Stroke. Frontiers in Medical Science Research (2024), Vol. 6, Issue 3: 45-49. https://doi.org/10.25236/FMSR.2024.060308.
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