To observe whether pre-treatment with Jiawei Yuping Fengsan granules can alleviate secondary lung injury in ischemic stroke. 30 SPF grade male SD rats were randomly divided into three groups: sham surgery group (sham group), cerebral ischemia-reperfusion group (IR group), modified Yupingfeng powder particle pretreatment cerebral ischemia-reperfusion group (Y-IR group), sham surgery group: no intervention; IR group: equal amount of physiological saline; Y-IR group; Jiawei Yuping Fengsan granules 10mg/kg. After successful modeling, ischemia lasted for 3 hours and reperfusion lasted for 2 hours. After the experiment, the total cell count and neutrophil percentage in bronchoalveolar lavage fluid (BALF) were measured; Measure oxidative stress factors (MDA, SOD) in rat lung tissue and blood; The expression level of inflammatory factors (TNF- α, IL-1β and IL-6). Compared with the IR group, the expression levels of total cell count and neutrophil percentage in bronchoalveolar lavage fluid (BALF) of rats in the Y-IR group significantly decreased, with statistical significance (P<0.05). Compared with the IR group, the expression level of MDA in lung tissue and serum of rats in the Y-IR group significantly decreased, while SOD activity significantly increased, with statistical significance (P<0.05). Compared to the IR group, in the lung tissue and serum of rats in the Y-IR group , The expression level of TNF - α, IL-1β,IL-6 content significantly decreased, and the difference was statistically significant (P<0.05). Jiawei Yuping Fengsan Granules have a protective effect on secondary lung injury caused by ischemic stroke by inhibiting neutrophil aggregation, inhibiting inflammatory response, and alleviating oxidative stress.

Yongquan Liu, Luchang Yin. Jiawei Yuping Fengsan Granules Relieve Secondary Lung Injury in Ischemic Stroke. Frontiers in Medical Science Research (2024), Vol. 6, Issue 3: 45-49. https://doi.org/10.25236/FMSR.2024.060308.

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