Knee osteoarthritis (KOA) is a chronic joint disease characterized by articular cartilage degeneration and secondary hyperostosis. With the deepening of research on the prevention and treatment of knee osteoarthritis using Chinese herbal medicine, the prevention and treatment of knee osteoarthritis using Chinese medicine has been widely recognized and verified. Still, its mechanism has yet to be unified. Many studies have found that the Wnt/β-catenin signaling pathway is associated with the preventive and therapeutic effects of TCM in knee osteoarthritis. The author summarized the research progress of traditional Chinese medicine in preventing and treating knee osteoarthritis by affecting the Wnt/β-catenin signaling pathway regarding relevant literature in recent years. This paper reveals the mechanism of TCM intervention on the Wnt/β-catenin signaling pathway in the prevention and treatment of knee osteoarthritis. It brings new ideas to clinical research on TCM treatment of knee osteoarthritis.

Hongji Liu, Yinglin Zhao, Shuwen Zhang, Chaoxiang Wang. Research Progress of Traditional Chinese Medicine on Prevention and Treatment of Knee Osteoarthritis Based on Wnt/β-catenin Signaling Pathway. Frontiers in Medical Science Research (2024), Vol. 6, Issue 7: 69-76. https://doi.org/10.25236/FMSR.2024.060708.

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