This study explores the multidimensional impact of oral diseases on overall health, focusing on the associations between oral diseases and systemic conditions such as diabetes, cardiovascular diseases, cancer, Alzheimer's disease, and respiratory infections. The research indicates that periodontal diseases and other oral conditions significantly increase the risk of these systemic diseases through systemic inflammatory responses. An imbalance in the oral microbiome affects not only local oral health but also impacts overall health via the gut-oral axis, particularly by inducing low-grade chronic inflammation, which increases the risk of systemic diseases. Elevated levels of inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) in periodontal disease patients are closely associated with chronic conditions like cardiovascular diseases and diabetes. Effective management of oral health through multidisciplinary cooperation and comprehensive treatment can significantly reduce the risk of systemic diseases. Preventive and therapeutic strategies, including regular dental check-ups and professional cleanings, health education, oral hygiene promotion, and effective treatment of periodontal and oral infections, are crucial for improving both oral and overall health. Future research should further explore the complex mechanisms between the oral microbiome and overall health, develop new treatment and prevention strategies, and promote multidisciplinary collaboration and emerging technologies such as big data and artificial intelligence to achieve precise management and prediction. Global research collaboration and the establishment of shared data platforms will further advance oral health research and enhance overall health levels.

Weiwu Fei. The Multidimensional Impact of Oral Diseases on Overall Health. Frontiers in Medical Science Research (2024), Vol. 6, Issue 7: 90-97. https://doi.org/10.25236/FMSR.2024.060711.

[1] Su, C., Shigeishi, H., Nishimura, R., Ohta, K., & Sugiyama, M. (2018). Detection of oral bacteria on the tongue dorsum using PCR amplification of 16S ribosomal RNA and its association with systemic disease in middle-aged and elderly patients. Biomedical Reports, 10(1), 70-76. 

[2] Meurman, J., & Bascones-Martínez, A. (2021). Oral Infections and Systemic Health - More than Just Links to Cardiovascular Diseases. Oral Health & Preventive Dentistry, 19(1), 441-448. 

[3] Nazir, M., Izhar, F., Akhtar, K., & Almas, K. (2019). Dentists' awareness about the link between oral and systemic health. Journal of Family & Community Medicine, 26, 206-212. 

[4] Kapila, Y. (2021). Oral health’s inextricable connection to systemic health: Special populations bring to bear multimodal relationships and factors connecting periodontal disease to systemic diseases and conditions. Periodontology 2000, 87, 11-16. 

[5] Raittio, E., & Farmer, J. (2021). Methodological Gaps in Studying the Oral-Systemic Disease Connection. Journal of Dental Research, 100, 445-447. 

[6] Botelho, J., Mascarenhas, P., Viana, J., Proença, L., Orlandi, M., Leira, Y., Chambrone, L., Mendes, J., & Machado, V. (2022). An umbrella review of the evidence linking oral health and systemic health: from the prevalence to clinical and circulating markers. Journal of Evidence-Based Dental Practice. 

[7] Guest Editor Dr. K.M.K. Masthan. (2021). Oral Health and Systemic Diseases. International Journal of Life Science and Pharma Research.

[8] Schwarz, C., Hajdu, A. I., Dumitrescu, R., Sava-Rosianu, R., Bolchis, V., Anusca, D., Hanghicel, A., Fratila, A. D., Oancea, R., Jumanca, D., Galuscan, A., & Leretter, M. (2023). Link between Oral Health, Periodontal Disease, Smoking, and Systemic Diseases in Romanian Patients. Healthcare, 11. 

[9] Farrukh Imran Mian, Hamza, S., Wahid, A., & Bokhari, S. A. H. (2018). Medical and Dental Practitioners' Awareness about Oral-Systemic Disease Connections. Journal of Family & Community Medicine, 26, 151-157. 

[10] Salminen, A., Määttä, A., Mäntylä, P., Leskelä, J., Pietiäinen, M., Buhlin, K., Suominen, A.L., Paju, S., Sattler, W., Sinisalo, J., & Pussinen, P. (2023). Systemic Metabolic Signatures of Oral Diseases. Journal of Dental Research, 103, 13-21. 

[11] Carrizales-Sepúlveda, E. F., Ordaz-Farías, A., Vera-Pineda, R., & Flores-Ramírez, R. (2018). Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease. Heart, Lung & Circulation, 27(11), 1327-1334. 

[12] Casamassimo, P., Flaitz, C., Hammersmith, K., Sangvai, S. G., & Kumar, A. (2018). Recognizing the Relationship Between Disorders in the Oral Cavity and Systemic Disease. Pediatric Clinics of North America, 65(5), 1007-1032.