This study aims to investigate the efficacy of combining monocyte count and high-density lipoprotein ratio (MHR) with cystatin C in diagnosing lower extremity atherosclerotic disease (LEAD) in patients with essential hypertension (EH). A total of one hundred seventy-eight patients with EH were admitted to the Department of Family Medicine at the Second Affiliated Hospital of Guilin Medical College from July 2021 to December 2022. Among these patients, those who developed LEAD constituted the combined group (88 cases), while those who did not develop LEAD formed the control group (90 cases).A comparison between the two groups regarding age, history of coronary heart disease, white blood cell(WBC), red blood cell (RBC), hemoglobin(Hb), monocyte count, urea nitrogen, creatinine, cystatin C, total cholesterol(TC), and MHR revealed statistically significant differences (P < 0.05).Spearman rank correlation analysis revealed that the MHR was positively correlated with age, WBC,monocyte count, urea nitrogen , creatinine, uric acid, and TG . Conversely, MHR exhibited negative correlations with RBC, Hb , and HDL. Cystatin C was positively correlated with age, WBC, monocytes, urea nitrogen, creatinine, and uric acid. Additionally, cystatin C demonstrated negative correlations with RBC, Hb, and LDL. Furthermore, cystatin C was positively correlated with MHR. Multifactorial logistic regression analysis indicated that MHR and cystatin C are significant risk factors for the development of LEAD in patients with EH. The results of the receiver operating characteristic (ROC) curve analysis revealed that in patients with EH, the area under the ROC curve for MHR, cystatin C, and their combination in relation to the development of LEAD were 0.714 (95% CI: 0.639 - 0.788), 0.809 (95% CI: 0.745 - 0.873), and 0.834 (95% CI: 0.775 - 0.894), respectively. The optimal cut-off values were 0.398,1.275, 0.562, corresponding to sensitivities of 0.841, 0.693, 0.682,and specificities of 0.467, 0.800, 0.878, respectively. MHR and cystatin C are independent risk factors for the development of LEAD in patients with EH. Furthermore, there exists a positive correlation between these two factors, which holds predictive value for the onset of LEAD in this patient population.

Lei Wei, Liang Shengxiang, Fan Xianying. Diagnostic Efficacy of Monocyte Count and High-density Lipoprotein Ratio Combined with Cystatin C in the Diagnosis of Lower Extremity Atherosclerotic Disease in Patients with Essential Hypertension. Frontiers in Medical Science Research (2024), Vol. 6, Issue 9: 1-10. https://doi.org/10.25236/FMSR.2024.060901.

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