Triglycerides and glucose, key metabolic products in the human body, are linked to the onset of various chronic diseases. However, the relationship between the triglyceride-glucose (TyG) index and hypertension among middle-aged and elderly populations remains unclear. This study primarily aims to explore the association between the TyG index and the risk of developing hypertension in individuals aged 45 and older through a prospective cohort study approach. This research incorporated clinical data from 4,940 participants of the China Health and Retirement Longitudinal Study (CHARLS) spanning from 2011 to 2018. The TyG index was calculated for all participants using the formula ln [triglycerides (mg/dL) x plasma glucose (mg/dL) / 2]. Cox regression analysis was employed to assess the relationship between the TyG index and the onset of new hypertension, with adjustments made for pertinent variables. Participants were also stratified by demographic characteristics to further examine the consistency of the TyG index's relationship with new-onset hypertension. Over the 7-year observation period, 1,275 participants developed hypertension, accounting for 25.8% of the total cohort. Factors such as older age, higher body mass index, lower educational levels, and elevated TyG index were linked to a higher risk of developing hypertension. Significant correlations were observed between the TyG index and variables including participants’ height, weight, BMI, residential area, smoking habits, alcohol consumption, diabetes, heart disease, blood glucose, blood lipids, and uric acid levels. The likelihood of developing hypertension increased progressively with higher TyG index values, indicating a positive correlation. This positive relationship was consistent across various demographic and health-related subgroups. Within this Chinese cohort, the TyG index is a valuable predictor of the risk for new-onset hypertension. Consequently, in the realm of primary hypertension prevention, individuals with hyperlipidemia and diabetes should be identified as high-risk and receive targeted interventions.

Zhaoming Fu, Tianfeng Chen, Shunshun Zhang, Zhewei Shi. Predictive Value of the Triglyceride-Glucose (TyG) Index for New-Onset Hypertension in Chinese Individuals Aged 45 and Above: A National Longitudinal Cohort Study from CHARLS. Frontiers in Medical Science Research (2024), Vol. 6, Issue 9: 11-18. https://doi.org/10.25236/FMSR.2024.060902.

[1] Li L, Duan L, Xu Y, et al. Hypertension in frail older adults: current perspectives[J]. PeerJ, 2024,12:e17760.

[2] Katsimardou A, Imprialos K, Stavropoulos K, et al. Hypertension in Metabolic Syndrome: Novel Insights[J]. Curr Hypertens Rev, 2020,16(1):12-8.

[3] Sakr HF, Sirasanagandla SR, Das S, et al. Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control[J]. Biomedicines, 2023, 11(8).

[4] Xu J, Xu W, Chen G, et al. Association of TyG index with prehypertension or hypertension: a retrospective study in Japanese normoglycemia subjects [J]. Front Endocrinol (Lausanne), 2023, 14: 1288693.

[5] Zhao Y, Hu Y, Smith JP, et al. Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS) [J]. Int J Epidemiol, 2014,43(1):61-8.

[6] Zhang F, Zhang Y, Guo Z, et al. The association of triglyceride and glucose index, and triglyceride to high-density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross-sectional population study[J]. J Clin Hypertens (Greenwich), 2021,23(7): 1405-12.

[7] Wang Y, Yang W, Jiang X. Association between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis [J]. Front Cardiovasc Med, 2021, 8:644035.

[8] Zheng R, Mao Y. Triglyceride and glucose (TyG) index as a predictor of incident hypertension: a 9-year longitudinal population-based study [J]. Lipids Health Dis, 2017, 16(1):175.

[9] Sakr HF, Sirasanagandla SR, Das S, et al. Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control[J]. Biomedicines, 2023, 11(8).

[10] Manrique C, Lastra G, Gardner M, et al. The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress[J]. Med Clin North Am, 2009, 93(3): 569-82.

[11] Sinha S, Haque M. Insulin Resistance Is Cheerfully Hitched with Hypertension[J]. Life (Basel), 2022, 12(4).

[12] Sarafidis PA, Bakris GL. Insulin resistance, hyperinsulinemia, and hypertension: an epidemiologic approach [J]. J Cardiometab Syndr, 2006, 1(5):334-42.