With the increasing incidence rate and mortality of malignant tumors, the means of treatment for malignant tumors are also growing, but radiotherapy is still one of the important means of treatment for tumor patients. However, the toxic side effects of radiotherapy make it difficult for patients to tolerate the subsequent pain and psychological pressure, leading to the termination or interruption of treatment, thereby reducing the efficacy of radiotherapy and causing tumor progression. Modern research has shown that the combination of traditional Chinese medicine and radiotherapy can improve adverse reactions caused by radiotherapy, enhance the body's immunity and clinical efficacy, improve patients' quality of life, and prolong survival. This article reviews the research progress on the toxic side effects of traditional Chinese medicine on radiotherapy for malignant tumors in recent years, providing a basis and suggestions for subsequent clinical research.

Guohao Wang, Yami Zhang. Research Progress on Improving the Toxic Side Effects of Tumor Radiotherapy with Traditional Chinese Medicine. Frontiers in Medical Science Research (2024), Vol. 6, Issue 9: 49-54. https://doi.org/10.25236/FMSR.2024.060908.

[1] Sang Lei, Dong Rui, Lu Mei, etc. Fascin:A biomarker of malignancy and poor prognosis [J]. Journal of Modern Oncology, 2021, 29 (18): 3304-3307. 

[2] Li Zhenzhen, Geng Yunping, You Guoqing, etc. VALUE of Dual-energy CT Imaging Omics in Angiogenesis and Clinical Prognosis Evaluation of Advanced Gastric Cancer [J]. The Practical Journal of Cancer, 2022, 37 (03): 467-470. 

[3] Jin Chongqiang, Quan Ying, Liu Haili, etc. Prevention and Treatment of Myelosuppression Caused by Radiotherapy by Traditional Chinese Medicine [J]. Journal of Taizhou University, 2017, 39 (06): 18-21. 

[4] Cai Xiaoyue, Xu Zhenye. Research Advance on Treatment of Bone Marrow Suppression from Kidneys [J]. Shanghai Journal of Traditional Chinese Medicine, 2007 (07): 75-77. 

[5] Wang Zhenqiang, Chen Baoyi, Li Xiaojiang, etc. Clinical and basic research progress on the treatment of bone marrow suppression after chemotherapy based on deficiency theory [J]. Chinese Medicine Modern Distance Education of China, 2010, 8 (24): 2022-204. 

[6] Liu Jun, Ding Yuyou, Meng Chunqin, etc. A Brief Discussion of Spleen and Kidney in the Prevention and Treatment of Bone Marrow Suppression Caused by Chemotherapy [J]. Anti-Tumor Pharmacy, 2014, 4 (02): 103-106. 

[7] Lu Qing, Zhao Lei, Jiang Ke, etc. Clinical Observation of “Wenshen Shengbai Decoction”for Myelosuppression Induced by Chemotherapy for Postoperative Breast Cancer [J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2014, 28 (03): 29-31. 

[8] Liu Yao, Shi Ying, Liu Zhirui, etc. Protective Effects of Astragali Radix Polysaccharides Combined with Astragaloside Ⅳ against Radiation Injury Model Mice [J]. China Pharmacy, 2014, 25 (03): 211-214. 

[9] Huang Ying, Liang Xiaoyan, Li Chengjin, etc. Ease effect of ginsenoside on different-intensity ionizing radiation damage to human hematopoietic stem cells [J]. Chinese Journal of Tissue Engineering Research, 2015, 19 (01): 124-129. 

[10] Qi Lin, Wu Wenqian, Chen Shaohua, etc. Protective effect of antioxidation of flavonoids of Astragali complanali against radiation damage [J]. Shanghai Journal of Traditional Chinese Medicine, 2011, 45 (05): 73-77. 

[11] Shi Yaping, Zhu Bide, Huang Qian, and others. Effect of Shi-Quan-Da-Bu-Granule on routine blood and erythropoietin on myelosuppressed mice [J]. Laboratory Medicine and Clinic, 2009,6 (15): 1221-1223. 

[12] Jiang Tao, Chen Gang, Xia Lina, etc. Experimental study on hematopoietic regulation of irradiated bone marrow suppression mice by Zuogui Wan and Yougui Wan decoction [J]. Asia-Pacific Traditional Medicine, 2014, 10 (07): 4-6. 

[13] Chen Jiaojiao, Hu Lingjing, Zhang Guoduo, etc. Effect of Sijunzi Tang on Bone Marrow Suppression of Lung Cancer in Chemotherapy [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24 (02): 180-185. 

[14] Wang Changfu, Xu Jiazhi, Wang Siyu, etc. Study on the chemical constituents of antibacterial part from Medicated Leaven Massa [J]. Lishizhen Medicine and Materia Medica Research, 2020,31 (10): 2350-2353. 

[15] Song Yuanyuan. Clinical observation of Banxia Xiexin Tang combined with Sijunzi Tang in the treatment of chemotherapy-induced gastrointestinal reactions [J]. Shaanxi Journal of Traditional Chinese Medicine, 2016, 37 (05): 578-579. 

[16] Zong Xiaoming. Yinxuan Xiexin Tang for the treatment of 59 cases of diarrhea caused by fluorouracil [J]. Modern Chinese Medicine, 2018, 38 (05): 28-29.

[17] Lu Xiyan, Zhao Ningxia. Clinical efficacy of Wumei Wan combined with Sijunzi Tang in the treatment of radiation enteritis and its impact on inflammatory factors in patients [J]. Shanxi Medical Journal, 2022, 51 (13): 1503-1505. 

[18] Hou Guilan, Lu Baizhen, Wang Chunlei. Analysis of Chinese Medicine in Prevention and Treatment for Gastrointestinal Toxicity Induced by Chemotherapy [J]. Chinese Archives of Traditional Chinese Medicine, 2008 (08): 1799-1801. 

[19] Jiang Lin, Zhao Canjun, Jiao Jing, etc. Clinical Observation of Qingre Liangxue Jiedu Decoction Enema in the Treatment of Acute Radiation Enteritis Caused by Radiotherapy of Cervical Cancer [J]. World Journal of Integrative Medicine, 2022, 17 (02): 311-314+318. 

[20] Tian Shiyu, Yu Yonghua, Chen Yantiao, etc. The Effects of the Ointment of Chinese Traditional Medicine Treated the acute and Radioactivity Skin Trauma [J]. Journal of Cancer Prevention and Treatment, 2002 (04): 438-439. 

[21] Miao Qinghong, Wu Ningbo, Chen Jing, etc. Study on the Improvement Effect of Yuchuang Zicao Oil on Radiation induced Skin and Mucosal Injury in Patients with Head and Neck Malignant Tumors [J]. Advances in Modern Biomedicine, 2024, 24 (10): 1873-1877.

[22] Zhao Wenyu, Si Fuchun, Wang Wenbin, etc. Research progress on the therapeutic effect of traditional Chinese medicine injection on esophageal cancer [J]. Chinese Journal of Experimental Pharmacology, 2021, 27 (15): 227-234. 

[23] Qi Runzhi. Pathological changes of lung tissue and the semi-quantitative analysis of alveolar inflammation of rats in the model of acute radiation induced lung injury treated with Shashen Jiegeng Decoction [D]. China Journal of Traditional Chinese Medicine and Pharmacy, 2018.