In order to study the prognostic factors of elderly patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure and the effect of personalized nursing and diversified education, the clinical data of 142 elderly patients with COPD complicated with respiratory failure admitted to our hospital from September 2021 to August 2023 were collected. According to the results of 1-year follow-up, they were divided into poor prognosis group (n=46) and good prognosis group (n=96). The clinical data of the two groups were compared to analyze the prognostic factors of elderly COPD patients with respiratory failure and the value of each factor in predicting poor prognosis of patients.The results showed age, Partial Pressure of Carbon Dioxide (PaCO2), Acute physiology and chronic health in the poor prognosis group The APACHE Ⅱ score, N-terminal pro-brain natriuretic peptide (NT-proBNP) and High-sensitivity troponin (hs-cTn) levels were higher than those in the good prognosis group. The oxygenation index of the group with good prognosis was significantly lower than that of the group with good prognosis (P < 0.05).Multivariate analysis showed that age, PaCO2, oxygenation index, NT-proBNP, hs-cTn levels and APACHEⅡ score were independent risk factors for poor prognosis in elderly COPD patients with respiratory failure (P < 0.05).The results of receiver operating characteristic (ROC) curve showed that: Age, PaCO2, oxygenation index, NT-proBNP, hs-cTn levels, APACHEⅡ score and combined prediction of poor prognosis in elderly COPD patients with respiratory failure were statistically significant (P < 0.05), and the AUC of combined prediction was 0.993, 95%CI was 0.982-1.000. The sensitivity and specificity were 0.957 and 0.979, respectively.In conclusion, the combination of age, PaCO2, oxygenation index, NT-proBNP, hs-cTn levels and APACHEⅡ score has a high value in predicting the poor prognosis of elderly COPD patients with respiratory failure. Therefore, it is necessary to pay close attention to the above factors and take targeted measures to improve the prognosis of patients.

Yu Feifei. Research on the Related Influencing Factors of Prognosis, Personalized Nursing, and Diversified Education Effects in Elderly Patients with COPD and Respiratory Failure. Frontiers in Medical Science Research (2024), Vol. 6, Issue 11: 30-36. https://doi.org/10.25236/FMSR.2024.061106.

[1] Zeng Jing, Jiang Yong, Zhu Lin. Relationship between extravascular lung water index and intrathoracic blood volume index and prognosis in elderly patients with chronic obstructive pulmonary disease complicated with respiratory failure [J]. Geriatrics and Health Care,2020,26(6):1004-1008.

[2] LIANG Xueling, He Ping, CAO Jingjing, et al. Effect of hospital-community-family-individual prevention and control system for chronic obstructive pulmonary disease on prevalence, awareness and accuracy of chronic obstructive pulmonary disease [J]. Chin J Med,2023,44(10):1279-1282.

[3] Zhao Xiaoqiu, Tao Yunzhen, Yan Xiaomei, et al. Prognostic value of serum ACTA combined with extravascular lung water index in elderly patients with chronic obstructive pulmonary disease complicated with respiratory failure [J]. Journal of Ningxia Medical University, 2023,45(7):689-693,698.

[4] Wang Fengyan, Zhang Dongying, Liang Zhenyu, et al. Interpretation of the guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease (2021 revision) for general practitioners [J]. Chin J General Med,2021,24(29):3660-3663,3677.

[5] Ma Xiangbing, Long Chao, Guo Jian. Changes of serum CysC, IL-6 and ACTA levels in elderly patients with COPD and RF and their correlation with acute attack and prognosis [J]. J Molecular Diagnosis and Therapy,2023,15(3):531-535.

[6] Chen Yan, Li Xiaomei. Risk factors and risk model construction of respiratory failure in elderly patients with acute exacerbation of chronic obstructive pulmonary disease [J]. Chin J Gerontology, 2012,42(22):5478-5480.

[7] Yang Zhao-guo, Wang Hua-qiang, Huang Hong-li. Correlation analysis of serum levels of ACTA, CXCL12 and hs-CRP with disease outcome in elderly patients with chronic obstructive pulmonary disease complicated with respiratory failure [J]. Lab Med & Clin, 2021,21(10):1468-1471,1477.

[8] Xiao Xin, LIANG Fengying, Guo Chaowen, et al. Effects of high-flow oxygen therapy on oxygenation index and prognosis in elderly patients with chronic obstructive pulmonary disease complicated with type Ⅱ respiratory failure [J]. Chin J Healthcare Med, 2021,26(3):370-373.

[9] REN Qing-wei, ZHANG Ju-wei, LI Kun, et al. Changes and significance of serum MCP-1, ACTA, hs-cTnT and NT-proBNP levels in elderly patients with chronic obstructive pulmonary disease complicated with respiratory failure [J]. Chin J Gerontology,2023,43(7):1574-1577.

[10] Xu Li, Zhang Meng, Zhang Dongya. Model construction of driving factors and nursing intervention strategies for ventilator-associated pneumonia in elderly patients with chronic obstructive pulmonary disease and respiratory failure undergoing mechanical ventilation [J]. Chinese Medicine Review, 2020,20(32):139-143.