Neonatal early-onset sepsis (EOS) is one of the most common and life-threatening infections in neonates. This condition typically occurs within the first 72 hours after birth and is caused by pathogens transmitted from mother to infant. Common pathogens include Gram-positive bacteria, Gram-negative bacteria, and fungi. With the abuse of antibiotics and the emergence of resistant strains, the treatment of neonatal sepsis faces significant challenges. This article aims to analyze the pathogen distribution characteristics and resistance mechanisms of neonatal EOS, explore common resistant strains and their impact on clinical treatment, and propose management and prevention strategies, including rational use of antibiotics, infection control, and resistance monitoring. The study shows that the increase in resistant pathogens not only prolongs treatment durations but also complicates clinical management. Therefore, the rational use of antibiotics, enhanced infection control measures, and resistance monitoring are key to preventing and controlling early-onset sepsis.

Liu Jiajia, Shi Yuan. Pathogen Distribution Characteristics and Antibiotic Resistance Analysis of Neonatal Early-Onset Sepsis. Frontiers in Medical Science Research (2024), Vol. 6, Issue 12: 1-7. https://doi.org/10.25236/FMSR.2024.061201.

[1] Yang Yingtian, You Ting, Liu Xiaocheng, et al. A comparative analysis of pathogens and drug sensitivity in preterm and term neonates with early-onset sepsis. Chongqing Medicine, 2022, 51:2272-2276, 2281.

[2] Li Wenlin, Yang Ling, Zhong Lihua, et al. Pathogens and clinical features of early-onset and late-onset neonatal sepsis. Chinese Journal of Hospital Infection, 2022, 32(7):5.

[3] Feng Qiongqiong. Clinical features and pathogen analysis of early-onset and late-onset neonatal sepsis. Anhui Medical University, 2023. 

[4] Qiao Yanyan, Li Yan, Li Mingchao, et al. Clinical features, pathogen distribution, and antibiotic resistance in 151 cases of neonatal sepsis. Chinese Journal of Rational Drug Use, 2023, 20(5):74-79.

[5] Yao Shenjia, Zhang Xiaoqun, Li Haiying, Zhong Xiuli, Zhou Nina, Chen Shuiling, Shi Mimi. Clinical feature analysis of early-onset and late-onset neonatal sepsis. Traffic Medicine, 2023.