Interferon type I (IFN-I) plays a key role in intrinsic immunity against viruses and its production is associated with the recognition of intracytoplasmic non-self DNA by the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signalling pathway, as well as the recognition of downstream kinases TBK1 and interferon regulatory factor 3 (IRF3), which are the core of this signalling pathway. As the core part of this signalling pathway, its modification and stability are crucial for the correct and effective generation of immune response. There are three main regulatory mechanisms of STING: one is to promote or inhibit the STING signalling pathway through ubiquitination modification, the other is to regulate the duration and intensity of STING activation through phosphorylation. The third is to regulate the stability of the STING-TBK1 complex. The understanding of the regulatory mechanisms of STING function provides new avenues for the treatment of viral and inflammatory diseases.

Jiahao Wang, Qinglu Zhao, Ganwu Li, Lajia Zhou, Laiyibu Hei, Weichang Liu, Rui Zhang. Research Progress in the Mechanism of Functional Regulation of STING. Frontiers in Medical Science Research (2024), Vol. 6, Issue 12: 51-56. https://doi.org/10.25236/FMSR.2024.061208.

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