Frontiers in Educational Research, 2025, 8(2); doi: 10.25236/FER.2025.080203.
Zhen Dai1, Lifeng Zhao1, Zongyuan Zhou1, Yong Li2
1Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, China
2School of Pharmacy, Chongqing University of Arts and Sciences, Chongqing, China
Recent breakthroughs in life sciences technologies and artificial intelligence have significantly increased the demand for innovative and interdisciplinary pharmaceutical professionals. Traditional teaching models in medicinal chemistry are facing unprecedented challenges and require urgent reform and transformation. In order to meet the training goals and needs of pharmaceutical professionals and enhance the innovative thinking and scientific literacy of undergraduate students in pharmaceutical sciences, this study explores innovative reforms in the teaching model of medicinal chemistry, encompassing both theoretical instruction and laboratory experiments. The study focuses on the characteristics of the Medicinal Chemistry course, evaluates the current state of medicinal chemistry education, and explores the approaches for reforming both theoretical and experimental teaching in Medicinal Chemistry.
Medicinal Chemistry, Innovative teaching, Literature reading, Computer-aided drug design, Sulfacetamide sodium, Pharmacological evaluation
Zhen Dai, Lifeng Zhao, Zongyuan Zhou, Yong Li. Innovative Reforms in Medicinal Chemistry Teaching: From Theory to Experiments. Frontiers in Educational Research (2025) Vol. 8, Issue 2: 14-20. https://doi.org/10.25236/FER.2025.080203.
[1] Li W, Ouyang Y, Xu J, et al. Implementation of the Student-Centered Team-Based Learning Teaching Method in a Medicinal Chemistry Curriculum[J]. J Chem Educ, 2022, 99(5): 1855.
[2] Panzarella G, Gualtieri G, Romeo I, et al. MedChemBlog: An Innovative Distance Learning Experience for Teaching Medicinal Chemistry[J]. J Chem Educ, 2022, 100(1): 232.
[3] U.S. Food and Drug Administration, Novel Drug Aprrovals for 2024. https://www.fda.gov/drugs/novel-drug-approvals-fda/novel-drug-approvals-2024 (accessed 31 December 2024).
[4] Wang J. B., Zhang Y. Strategies for Introducing Frontier Content into Medicinal Chemistry Teaching [J]. Pharmaceutical Education, 2021, 37(06): 35. (in Chinese)
[5] Touaibia M, Levesque N A. Synthesis, Copper Chelation, and Free Radical Scavenging Ability of Edaravone: An Undergraduate Medicinal Chemistry Laboratory Experiment[J]. J Chem Educ, 2024, 101(11): 4924.
[6] Garzón-Posse F, Quevedo-Acosta Y, Gamba-Sánchez D. Paracetamol Synthesis for Active Learning of Amide Functional Groups in Undergraduate Chemistry Laboratories[J]. J Chem Educ, 2022, 99(6): 2385.
[7] Che T, Roth B L. Molecular basis of opioid receptor signaling[J]. Cell, 2023, 186(24): 5203.
[8] Vo Q N, Mahinthichaichan P, Shen J, et al. How mu-opioid receptor recognizes fentanyl[J]. Nat Commun, 2021, 12(1): 984.
[9] Zhuang Y, Wang Y, He B, et al. Molecular recognition of morphine and fentanyl by the human mu-opioid receptor[J]. Cell, 2022, 185(23): 4361.
[10] Orlando B J, Lucido M J, Malkowski M G. The structure of ibuprofen bound to cyclooxygenase-2[J]. J Struct Biol, 2015, 189(1): 62.