This manuscript endeavors to synthesize the latest advancements in targeted therapy for vitiligo and to elucidate its future trajectories. Vitiligo, a widespread dermatological condition, is characterized by an incompletely understood etiology and pathological underpinnings, with contributions from genetic predisposition, immune dysregulation, and environmental triggers. Of late, targeted therapy has emerged as a promising avenue for vitiligo patients, particularly those refractory to conventional therapies. This paper emphasizes the developmental milestones and clinical trial outcomes of innovative targeted agents, notably JAK inhibitors. By selectively modulating immune pathways, these therapies demonstrate efficacy in fostering melanocyte regeneration and enhancing cutaneous pigmentation among patients. Additionally, this paper anticipates the forthcoming research orientations in targeted therapy for vitiligo. A profound elucidation of the molecular machinations underpinning vitiligo will catalyze the formulation of more potent targeted therapeutic interventions, thereby enabling personalized medical approaches and furnishing patients with more scientifically rigorous and systematically structured treatment paradigms.

Zhao Jiemei. Latest Research Progressions and Future Perspectives on Targeted Therapy in Vitiligo. Frontiers in Medical Science Research(2025), Vol. 7, Issue 2: 6-10. https://doi.org/10.25236/FMSR.2025.070202.

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