Frontiers in Medical Science Research, 2025, 7(2); doi: 10.25236/FMSR.2025.070219.
Haiyan Zhu1,2,3, Shenglong Mo2,3, Chongdong Jian2,3
1Graduate School, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
2Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
3Key Laboratory of Prevention and Treatment of High Incidence Diseases in Westrn Guangxi, Guangxi Colleges and Universities, Baise, Guangxi, 533000, China
Current PD treatment mainly relies on traditional symptomatic therapy, with new drugs having great potential. Kuding tea, a Chinese medicine with antioxidant properties, might treat PD via antioxidant-driven anti-aging, but its exact mechanism is unclear. This study, combining network pharmacology, differential analysis, PPI network, single-cell analysis, and molecular docking, identified 72 common targets (e.g., CCND1, BCL2L1, PARP1) related to apoptosis, oxidative stress, cell cycle regulation, and the JAK-STAT pathway. Molecular docking confirmed their potential roles, suggesting Kuding tea's components could influence these proteins and pathways, affecting oxidative stress, aging, and inflammation repair in PD treatment, and offering a new research direction for its therapeutic mechanism.
Kuding tea; Aging; Parkinson's disease; JAK-STAT pathway
Haiyan Zhu, Shenglong Mo, Chongdong Jian. Mechanisms of kudingcha tea in treating Parkinson's disease: a network pharmacology and molecular docking study. Frontiers in Medical Science Research (2025), Vol. 7, Issue 2: 131-137. https://doi.org/10.25236/FMSR.2025.070219.
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