Frontiers in Medical Science Research, 2025, 7(3); doi: 10.25236/FMSR.2025.070319.
Zukang Deng1, Ting Jiang1, Linlu Chen1, Xiaoyi Huang1, Yongfu Tang1, Linfeng Zhong1, Jiaguo Liang1, Chaoyuan Yang1, Wenjin Huang1, Shuqiu Zhang2, Qijun Long3,4
1College of Clinical Medical, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
2Guangxi Xinghuo Biotechnology Co., Ltd., Baise, Guangxi, 533000, China
3College of Humanities and Management, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China
4College of Innovation and Entrepreneurship, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China
This study compared the effects of tremella and its compound polysaccharides on subchronic aluminum-induced Alzheimer's disease (AD) in mice. Sixty mice were divided into normal, model (aluminum maltol-induced), tremella preparation (Treatment 1), and tremella compound polysaccharide (Treatment 2) groups. After modeling, treatments were administered via gavage while maintaining aluminum exposure. Memory was assessed using water maze tests, and brain enzymes (β-secretase 1, α/γ-secretase, AchE) and serum biochemical markers were analyzed. Model mice showed significantly reduced brain α-secretase (P<0.05 vs. normal), validating AD modeling. Treatment 2 demonstrated stronger reduction in γ-secretase than Treatment 1 (P=0.008). Both treatments normalized blood indices (e.g., urea nitrogen), suggesting mechanisms via regulating enzyme activities (e.g., β-amyloid cleaving enzyme) and biochemical pathways. While sharing similar anti-AD mechanisms, the two preparations exhibited distinct advantages in modulating specific markers. Results highlight tremella-based traditional Chinese medicine treatments as potential interventions for aluminum poisoning-related AD, warranting further study.
Alzheimer's Disease; Aluminum Poisoning; Beta-Amyloid Cleaving Enzyme; Traditional Chinese Medicine Treatment
Zukang Deng, Ting Jiang, Linlu Chen, Xiaoyi Huang, Yongfu Tang, Linfeng Zhong, Jiaguo Liang, Chaoyuan Yang, Wenjin Huang, Shuqiu Zhang, Qijun Long. A Comparative Study on the Pathogenesis of Alzheimer's Disease Induced by Subchronic Aluminum Exposure Using Tremella and Its Compound Polysaccharides. Frontiers in Medical Science Research (2025), Vol. 7, Issue 3: 141-146. https://doi.org/10.25236/FMSR.2025.070319.
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