This study evaluated the efficacy of mindfulness-based online interventions for patients with breast cancer. A systematic review and meta-analysis was conducted across nine databases: CNKI, VIP, WanFang, PubMed, Web of Science, The Cochrane Library, Embase, CINAHL, and SinoMed. The search period was from the establishment of the databases to May 2025. We included randomized controlled trials examining the effects of mindfulness-based online interventions for patients with breast cancer. Two independent researchers performed literature screening according to predefined inclusion and exclusion criteria, followed by data extraction and methodological quality assessment. The systematic review and meta-analysis was performed using Review Manager 5.3 software. Finally, a total of 15 randomized controlled trials involving 1,379 participants were included. The meta-analysis results showed that mindfulness-based online interventions can effectively improve anxiety, depression, cancer-related fatigue, stress, sleep quality, self-efficacy, and quality of life. In conclusion, Mindfulness-based online interventions demonstrate significant efficacy in improving multidimensional health outcomes among patients with breast cancer.

Jinghan Yang, Liping Wang, Qianyu Zhang, Weichao Liu. Effects of Mindfulness-Based Online Interventions in Patients with Breast Cancer: A Systematic Review and Meta-Analysis. Frontiers in Medical Science Research (2025), Vol. 7, Issue 5: 1-8. https://doi.org/10.25236/FMSR.2025.070501.

[1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3): 229-263.

[2] Lovelace D L, McDaniel L R, Golden D. Long-Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care[J]. J Midwifery Womens Health, 2019, 64(6): 713-724.

[3] Whisenant M, Wong B, Mitchell S A, et al. Symptom Trajectories Are Associated With Co-occurring Symptoms During Chemotherapy for Breast Cancer[J]. J Pain Symptom Manage, 2019, 57(2): 183-189.

[4] Zhu P T, Liu X Y, Shang X C, et al. Mindfulness-Based Stress Reduction for Quality of Life, Psychological Distress, and Cognitive Emotion Regulation Strategies in Patients With Breast Cancer Under Early Chemotherapy-a Randomized Controlled Trial[J]. Holistic Nursing Practice, 2023, 37(3): 131-142.

[5] Kabat-Zinn J. Mindfulness-Based Interventions in Context: Past, Present, and Future[J]. Clinical Psychology: Science and Practice, 2003, 10: 144-156.

[6] Schuman-Olivier Z, Trombka M, Lovas D A, et al. Mindfulness and Behavior Change[J]. Harv Rev Psychiatry, 2020, 28(6): 371-94.

[7] Özmaya E, Uzun S, Aytaç T. The Effect of a Mindfulness-Based Stress Reduction Program on Depression and Quality of Life in Cancer Patients: A Meta-Analysis Study[J]. Holist Nurs Pract, 2024.

[8] Bindicsova I, Hides L M, Brain K, et al. Internet-delivered Mindfulness-Based Cognitive Therapy (iMBCT) for Chronic Pain Symptom Management in Adults: A Pilot Randomized Controlled Trial[J]. The Journal of Pain, 2025, 32: 105429.

[9] Xu F, Zhang J, Xie S, et al. Effects of Mindfulness-Based Cancer Recovery Training on Anxiety, Depression, Post-Traumatic Stress Disorder, and Cancer-Related Fatigue in Breast Neoplasm Patients Undergoing Chemotherapy[J]. Medicine (Baltimore), 2024, 103(23): e38460.

[10] Price-Blackshear M A, Pratscher S D, Oyler D L, et al. Online Couples Mindfulness-Based Intervention for Young Breast Cancer Survivors and Their Partners: A Randomized-Control Trial[J]. Journal of Psychosocial Oncology, 2020, 38(5): 592-611.

[11] Jing S, Zhang A, Chen Y, et al. Mindfulness-based interventions for breast cancer patients in China across outcome domains: a systematic review and meta-analysis of the Chinese literature[J]. Support Care Cancer, 2021, 29(10): 5611-21.

[12] Wang L, Chen X, Peng Y, et al. Effect of a 4-Week Internet-Delivered Mindfulness-Based Cancer Recovery Intervention on the Symptom Burden and Quality of Life of Patients With Breast Cancer: Randomized Controlled Trial[J]. Journal of Medical Internet Research, 2022, 24(11).

[13] Juarez-Reyes M, Martinez E, Xiao L, et al. A Randomized Controlled Trial of a Culturally Adapted, Community-Based, Remotely Delivered Mindfulness Program for Latinx Patients With Breast Cancer is Acceptable and Feasible While Reducing Anxiety[J]. Global Advances in Integrative Medicine and Health, 2024, 13.

[14] Rosen K D, Paniagua S M, Kazanis W, et al. Quality of life among women diagnosed with breast Cancer: A randomized waitlist controlled trial of commercially available mobile app-delivered mindfulness training[J]. Psychooncology, 2018, 27(8): 2023-30.

[15] Fung J Y T, Lim H, Vongsirimas N, et al. Effectiveness of eHealth mindfulness-based interventions on cancer-related symptoms among cancer patients and survivors: A systematic review and meta-analysis[J]. J Telemed Telecare, 2024, 30(3): 451-65.

[16] Higgins J P, Altman D G, Gøtzsche P C, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials[J]. BMJ, 2011, 343: d5928.

[17] Wang M, Chen H, Yang F, et al. Effects of digital psychotherapy for depression and anxiety: A systematic review and bayesian network meta-analysis[J]. J Affect Disord, 2023, 338: 569-580.

[18] Yu C, Zhang J, Pan G Q, et al. Application of internet-based mindfulness-based cognitive therapy in breast cancer rehabilitation patients[J]. Contemporary Nurse (Late Issue), 2022, 29(1): 1-5.

[19] Fu S J, Qu L L. Effects of virtual reality-based mindfulness intervention on quality of life and cancer-related fatigue in elderly breast cancer patients undergoing chemotherapy[J]. Geriatrics & Health Care, 2025, 31(1): 42-6+52.

[20] Guo Y. Application of a home-based intervention platform based on mindfulness-based stress reduction in postoperative breast cancer patients at high risk for deep vein thrombosis[J]. Journal of Mathematical Medicine, 2021, 34(4): 598-9.

[21] Shen A M, Qiang W M, Wang Q, et al. Effects of online mindfulness-based cancer recovery on perceived stress, fatigue, and anxiety in transitional breast cancer survivors[J]. Journal of Nurses Training, 2021, 36(23): 2113-6,2123.

[22] Ban Y, Bai H, Du Z, et al. Effects of online mindfulness-based stress reduction training on mental health in postoperative breast cancer patients[J]. Journal of Guangdong Medical University, 2025, 43(3): 287-92.

[23] Liu Y, Yang X L. Application of mindfulness nursing and sleep intervention with information technology in postoperative chemotherapy for breast cancer[J]. Journal of Women and Children's Health, 2023, 2(6): 152-154+60.

[24] Yegane Z A, Nasiri A, Sahranavard S, et al. Effect of Online Mindfulness-based Stress Reduction Intervention on Sleep Quality of Breast Cancer Patients[J]. Modern Care Journal: Scientific Quarterly of Birjand Nursing & Midwifery Faculty, 2024, 21(1): 1-8.

[25] Gu C, Peng Y, Peng Y, et al. Effects of a 4-week internet-delivered mindfulness-based cancer recovery program on anxiety, depression, and mindfulness among patients with breast cancer[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2024, 49(7): 1130-42.

[26] Peng L, Yang Y, Chen M, et al. Effects of an online mindfulness-based intervention on Fear of Cancer Recurrence and quality of life among Chinese breast cancer survivors[J]. Complementary Therapies in Clinical Practice, 2022, 49.

[27] Chen Y, Liu R, Xiao J, et al. Effects of online mindful self-compassion intervention on negative body image in breast cancer patients: A randomized controlled trail[J]. European Journal of Oncology Nursing, 2024, 72.

[28] Chang Y C, Yeh T L, Chang Y M, et al. Short-term Effects of Randomized Mindfulness-Based Intervention in Female Breast Cancer Survivors: A Systematic Review and Meta-analysis[J]. Cancer Nurs, 2021, 44(6): E703-e14.

[29] Shao D, Zhang H, Cui N, et al. The efficacy and mechanisms of a guided self-help intervention based on mindfulness in patients with breast cancer: A randomized controlled trial[J]. Cancer, 2021, 127(9): 1377-86.

[30] Duan Y F, Wang H R, Xu H J, et al. Aromatherapy combined with acupoint massage alleviates fatigue and sleep disturbances in breast cancer patients undergoing postoperative chemotherapy[J]. Journal of Nursing Science, 2022, 37(17): 50-54.

[31] Guo J D, Gong M. Effects of mindfulness-based stress reduction on fatigue and insomnia in breast cancer patients during chemotherapy[J]. Chinese and Foreign Medical Treatment, 2021, 40(12): 131-133.