1,2, Xiuqiong Deng 3

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Frontiers in Medical Science Research, 2020, 2(4); doi: 10.25236/FMSR.2020.020403.

Recent Development and Challenge of Glucose Sensing: a Review


Dingcheng Yang1,2, Xiuqiong Deng 3

Corresponding Author:
Dingcheng Yang

1 Australian National University, Canberra, 2600, Australia
2 Northwestern Polytechnical University, Xi'an Shaanxi, 710072, P.R. China
3 Zhejiang Huanlong Environmental Protection Co., Ltd., Hangzhou Zhejiang Province, 310012, P.R.China


As the number of diabetes patients escalates, glucose monitoring has been an emergent need for the diabetic people. Continuous glucose sensing (CGM) and self-monitoring of blood glucose were proposed to realize real-time management of blood glucose level. With the aid of these devices, it is possible that diabetes patients can modify their treatment and therapies accordingly. This paper reviews the constitute of typical CGM systems, the category of CGM and mechanism by analyzing experiment results and existing commercial products. SMBG, a point-sample blood glucose testing, is briefly discussed. Although glucose monitoring has convincible performance in laboratory, they are not applied widely due to some shortcomings. Several challenges are issued and their future trends are briefed. The review concludes that a user-friendly, painless products would be developed and is promising to benefit the diabetic patients.


Continuous glucose sensing (cgm), Self-monitoring of blood glucose (smbg), Diabetes

Cite This Paper

Dingcheng Yang, Xiuqiong Deng. Recent Development and Challenge of Glucose Sensing: a Review. Frontiers in Medical Science Research (2020) Vol. 2 Issue 4: 20-28. https://doi.org/10.25236/FMSR.2020.020403.


[1] K. Polonsky (2012). The past 200 Years in Diabetes. The new Journal of Medicine, vol. 367, no.12 pp. 1332-1340.
[2] K.-H. Lubert and K. Kalcher (2010). History of Electroanalytical Methods. Electroanalysis, vol. 22, no. 17, pp. 1937-1946.
[3] T. Blevins, B. Bode, S. Garg, G. Grunberger, I. Hirsch, et al. (2010). Statement by the American Association of Clinical Endocrinologists Consensus Panel on continuous glucose monitoring. Endocr Pract, vol. 16, no.5 pp. 730-745.
[4] H. Lee, Y. J. Hong, S. Baik, T. Hyeon and a. D.-H. Kim (2018). Enzyme-Based Glucose Sensor: From Invasive to Wearable Device. Advanced healthcare materials, vol. 7, no. 14, pp.158-162.
[5] G. Valdés-Ramírez, Y.-C. Li, J. Kim, W. Jia, A. J. Bandodkar, et al (2014). Microneedle-based self-powered glucose sensor. Electrochemistry Communications, vol. 47, no.6, pp. 58-62.
[6] J. Li, P. Koinkar, Y. Fuchiwaki and M. Yasuzawa (2016). A fine pointed glucose oxidase immobilized electrode for low-invasive amperometric glucose monitoring. Biosensors and Bioelectronics, vol. 86, no.10, pp. 90-94.
[7] J. Yadav, A. Rani, V. Singh and B. M. Murari (2015). Prospects and limitations of non-invasive blood glucose monitoring using near-infrared spectroscopy. Biomedical Signal Processing and Control, vol. 18, no.6, pp. 214-227.
[8] W. V. Gonzales, A. T. M. Abbosh and Amin (2019). The Progress of Glucose Monitoring-A Review of Invasive to Minimally and Non-Invasive Techniques, Devices and Sensors. Sensors, vol. 19, no.9, pp. 800.
[9] HuanfenYao, A. J.Shum, Melissa, Cowan, IlkkaLähdesmäki and B. A.Parviz (2011). A contact lens with embedded sensor for monitoring tear glucose level. Biosensors and Bioelectronics, vol. 26, no. 7, pp. 3290-3296.
[10] Ming-YanJia, Qiong-ShuiWu, HuiLi, YuZhang, Ya-FengGuan and LiangFeng (2015). The calibration of cellphone camera-based colorimetric sensor array and its application in the determination of glucose in urine. Biosensors and Bioelectronics, vol.74, no. 15, pp. 1029-1037.
[11] S. K. Vashist (2012). Non-invasive glucose monitoring technology in diabetes management: A review. Analytica Chimica Acta, vol. 750, no.23, pp. 16-27.
[12] N. A. B. A. Salam, W. H. b. M. Saad and F. b. S. Zahariah Binti Manap (2016). The Evolution of Non-invasive Blood Glucose Monitoring System for Personal Application. Faculty of Electronic and Computer Engineering, vol. 8, no.23, pp. 59-65.
[13] T. Lin, A. Gal, Y. Mayzel and K. H. a. K. Bahartan (2017). Non-Invasive Glucose Monitoring: A Review of Challenges and Recent Advances. Curr Trends Biomedical Eng & Biosci, vol. 6, no. 5. pp.10-19
[14] P. Narkhede, S. Dhalwar and B. Karthikeyan (2016). NIR Based Non-Invasive Blood Glucose Measurement. Indian Journal of Science and Technology, vol. 9, no. 41, pp. 1-5.