Breast cancer (BC) is the most common cancer diagnosis in women, often referred to as the "pink killer" [1], and its incidence ranks first among female malignancies, accounting for 25% of all cancer cases and 15% of all cancer deaths in the world [2]. With the improvement of medical level, the treatment methods of breast cancer have become relatively mature, including chemical therapy, adjuvant chemotherapy, neoadjuvant chemotherapy (mainly anthracycline and zisanchun drugs), endocrine therapy (tamoxifen, etc.), anti-estrogen drugs, aromatase inhibitors, etc. [3].In recent years, the role of UGT2B7 in drug metabolism and prognosis has been gradually discovered. To summarize the important role of UGT2B7 in prognosis diagnosis in recent years. In this paper, we search for qualified research by searching Pubmed, Uniprot and Chinese knowledge network. The data analysis and conclusion are helpful to the glucuronidation of many therapeutic drugs, including opioid drugs (such as codeine, morphine, naloxone), anticancer drugs (such as antitumor drugs: epirubicin, diclofenac, naproxen, etc.). In each treatment, the prognostic effect of UGT2B7 is gradually reflected, which is expected to be an important prognostic index.

Yang Xiao, Mengcong Ma, Yichen Li. A Study on the Relationship between UGT2B7 Gene Polymorphism and Clinical Prognosis. Frontiers in Medical Science Research (2021) Vol. 3 Issue 2: 17-20. https://doi.org/10.25236/FMSR.2021.030205.

[1] Steven S Coughlin 1 Epidemiology of Breast Cancer in Women Adv Exp Med Biol. 2019; 1152:9-29.

[2] Hai Li*, Bo Hu*, Zhe Guo, Xueqing Jiang, Xinyu Su, and Xiaoyi Zhang Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy Yonsei Med J 2019 Jan;60(1):30-37

[3] Anbok Lee 1, Byung In Moon 2, Tae Hyun Kim 3 BRCA1/ BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies Ann Lab Med.2020 Mar; 40(2):114-121.

[4] Cook, Ian; Asenjo, Anna B.; Sosa, Hernando, et al. The Human UGT2B7 Nanodisc. Drug Metabolism and Disposition. 2020V48N3:198-204

[5] Pramod C. Nair1,2#, Nguyen Chau 1#, Ross A. McKinnon 2 and John O. Miners 1,2 Arginine-259of UDP-glycosyltransferase 2B7(UGT2B7) confers UDP-sugar selectivity 2020 Dec;98(6):710-718.

[6] Anaïs Glatard 1 2, Monia Guidi 2 3, Maria Dobrinas 1, Jacques Cornuz 4, Chantal Csajka 5 6, Chin B Eap 7 8Influence of body weight and UGT2B7 polymorphism on varenicline exposure in a cohort of smokers from the general population 2019 Jul;75(7):939-949 

[7] Ayappa V Subramaniam 1, Ashwaq Hamid Salem Yehya 2, Chern Ein Oon 3Molecular Basis of Cancer Pain Management: An Updated Review Polymorphic Variants in NR1I3and UGT2B7Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer:A Case-Control Study,2019 Sep 12;55(9):584.

[8] Zi-Zhao Yang 1, Li Li 2, Lu Wang 1, Ling-Min Yuan 1.etc The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants2017 Aug;38(8):1184-1194  [9] Mariamena Arbitrio 1, Francesca Scionti 2, Emanuela Altomare 2, Maria Teresa Di Martino 2.etc Polymorphic Variants in NR1I3 and UGT2B7 Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer: A Case-Control Study 2019 Aug;106(2):422-431

[10] NemethBT, VargaZV, WuWJ, etal.Trastuzumabcardiotoxicity:from clinical trials to experimental studies[J]. Br J Pharmacol, 2017, 174(21):3727-3748

[11] Hai Li*, Bo Hu*, Zhe Guo, Xueqing Jiang, Xinyu Su, and Xiaoyi Zhang Department of Thyroid and Breast Surgery, The Central Hospital of WuhanCorrelation of UGT2B7Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy 2019 Jan;60(1):30-37. 

[12] UGT2B7-161 Gene Polymorphism in Prediction of Heart Toxicity Risk in Patients with EC-TH Program-assisted Chemotherapy HER-2 Positive Breast Cancer

[13] Ping Wang 1 2, Xiao-Qian Lin 1 3, Wen-Ke Cai 4, Gui-Li Xu 1, Meng-Di Zhou 1 2, Mei Yang 1 3, Gong-Hao He 5 Effect of UGT2B7genotypes on plasma concentration of valproic acid:a meta-analysis 2018 Apr;74(4):433-442

[14] Nair PC, Chau N, McKinnon RA, Miners JO. Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity. Mol Pharmacol. 2020 Dec; 98(6):710-718.

[15] He Baoxia, Zhao Xiu-li, Zhang Wen-zhou, Research progress in the association of UGT2B7 gene polymorphism with tumor. Chinese Journal of Clinical Pharmacology, Vol. 31, No. 17, September 2015 (total No.199).

[16] Wang XJ, Wang GG, Wang G1UgT2B7-161 gene polymorphism predictive value of cardiotoxicity risk in patients receiving EC-TH adjuvant chemotherapy with HER-2 positive breast cancer. Journal of Clinical Oncology, January 2020, 25 (1).

[17] Cook, Ian; Asenjo, Anna B.; Sosa, Hernando, et al. The Human UGT2B7 Nanodisc. Drug Metabolism and Disposition. 2020V48N3:198-204