Frontiers in Medical Science Research, 2021, 3(2); doi: 10.25236/FMSR.2021.030207.
Yinxuan Pu1, Hao Sun1, Quan Yang1, Yu Su1, Shangyi Lv1, Bangxiu Zheng1, Xiangzhen Han1, Huiyu He1, 2
1First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, Xinjiang, 830054
2Institute of Stomatology, Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, 830054
Objective to review the development and applications and intervention factors of hypoxia-inducible factor 1α (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. Methods the literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α and its intervention factors plays a key role in angiogenicosteogenic coupling, and as an upstream regulator.
Tissue engineering, Hypoxia-inducible factor 1α, DFO, DMOG, Cocl2
Yinxuan Pu, Hao Sun, Quan Yang, Yu Su, Shangyi Lv, Bangxiu Zheng, Xiangzhen Han, Huiyu He. Research Progress of HIF- 1α and its Intervention Factors in Osteogenic Synthesis of Blood Vessels in Bone Marrow Mesenchymal Stem Cells. Frontiers in Medical Science Research (2021) Vol. 3 Issue 2: 24-28. https://doi.org/10.25236/FMSR.2021.030207.
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