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Frontiers in Medical Science Research, 2021, 3(3); doi: 10.25236/FMSR.2021.030309.

The mechanism and research progress of circRNA-microRNA in regulating osteogenesis


Yi Dong1, Shuai Shan1, Xiangzhen Han2, Yixuan Pu1, Weizhe Yang1, Huiyu He3

Corresponding Author:
Huiyu He

1The First Affiliated Hospital of Xinjiang Medical University, Physician, Master Student, Urumqi, Xinjiang, 830000, China

2The First Affiliated Hospital of Xinjiang Medical University, Physician, Urumqi, Xinjiang, 830000, China

3Department of Stomatology of the First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital) / Institute of Stomatology of Xinjiang Uygur Autonomous Region, Urumqi, China


Jaw defect and alveolar bone absorption are the main oral problems in today’s society. In recent years, studies have found that changes in the expression of different miRNAs can affect the osteogenic effects of stem cells. With the in-depth study of its upstream circRNA, it has been found that circRNA can pass it acts as a molecular sponge of microRNA to indirectly regulate osteogenesis, so how to select a suitable and stable circRNA has become the focus of attention. In this review, we have collected and sorted out circRNA and its functions, the application and process of mirRNA to regulate osteogenic differentiation, and a list of several miRNAs closely related to osteogenesis and relatively mature researches, aiming to find suitable circRNA upstream Therefore, it is expected to be used in the clinical repair of oral bone defects.


circRNA, microRNA, osteogenic differentiation jaw bone defect, tissue regeneration, bone marrow mesenchymal stem cells, molecular sponge

Cite This Paper

Yi Dong, Shuai Shan, Xiangzhen Han, Yixuan Pu, Weizhe Yang, Huiyu He. The mechanism and research progress of circRNA-microRNA in regulating osteogenesis. Frontiers in Medical Science Research (2021) Vol. 3 Issue 3: 41-46. https://doi.org/10.25236/FMSR.2021.030309.


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