Aim: to investigate the effect of early enteral nutrition (EEN) on immune function and inflammatory reaction in patients with severe acute pancreatitis (SPA). Methods: 70 patients with SPA were randomly divided into EEN group and DEN group (delayed enteral nutrition). On the basis of routine treatment, EEN group was treated with enteral nutrition support within 72 hours after onset, and DEN group was given enteral nutrition support therapy on the 5th day after onset, and the course of treatment was 2 weeks. The immune indexes, inflammatory cytokines and clinical symptoms were compared between the two groups before and after treatment.Results: after treatment, CD3 cells, CD4, CD4 / CD8 cells, NK cells, B lymphocytes and IgA, IgG, IgM (immunoglobulin) were increased in both groups (P < 0.05), and EEN group was higher than DEN group (P < 0.05 or P < 0.01). After treatment, the levels of TNF- α, IL-6, endotoxin and amylase in both groups were lower than those before treatment (P < 0.05), and the scores of acute physiology and chronic health in EEN group were lower than those in DEN group (P < 0.01). EEN) after treatment compared with DEN group (P < 0.01). The incidences of sepsis and multiple organ dysfunction syndrome in DEN group were lower than those in DEN group (P < 0 01), and the improvement time and hospitalization time in DEN group were shorter than those in DEN group (P < 0 01).Conclusion: EEN can improve the immune function of SAP patients and reduce the incidence of infectious complications.

Li Weiying, Li Yusi, Liu Min, Lu Jing, The effect of early immune enteral nutrition on the immune function and inflammatory response of patients with severe acute pancreatitis. Frontiers in Medical Science Research (2019) Vol. 1 Issue 1: 48-60. https://doi.org/10.25236/FMSR.20190105.

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