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Frontiers in Medical Science Research, 2021, 3(4); doi: 10.25236/FMSR.2021.030410.

The Role of IL-6 in Macrophage-Mediated Fibrosis in Alcoholic Chronic Pancreatitis


Baofeng Chen, Huan Zhang, Yun Liu

Corresponding Author:
Yun Liu

School of Basic Medical Sciences, North Sichuan Medical College, Nanchong 637000, China 


Alcoholic chronic pancreatitis has become one of the important factors that threaten the safety of human life and endanger human tissue cells for the occurrence and spread of metabolic syndrome diseases. Therefore, this article is studying the role of IL-6 in the disease, with the purpose of improving the level of medical treatment through the study of interleukins. This article mainly adopted the experimental method and the control method to test and analyze the signal pathway of IL-6 in stimulating the differentiation of macrophages, and then draw relevant conclusions, and found that it has a catalytic effect in macrophage-mediated fibrosis. Experiments show that the STAT3 in the experiment is greater than 0.5, and the STAT3 signal pathway is positively correlated with the IL-6 concentration.


IL-6, alcoholic chronic pancreatitis, macrophages, fibrosis

Cite This Paper

Baofeng Chen, Huan Zhang, Yun Liu. The Role of IL-6 in Macrophage-Mediated Fibrosis in Alcoholic Chronic Pancreatitis. Frontiers in Medical Science Research (2021) Vol. 3 Issue 4: 58-63. https://doi.org/10.25236/FMSR.2021.030410.


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