Mitochondria are the key organelles for life. Mitochondria are important mediators of tumorigenesis. Mitochondria are key participants in tumorigenesis and development. In-depth study on the role of mitochondria in the survival and growth of tumor cells is not only conducive to our understanding of tumor genesis and development, including oncogene activation, tumor suppressor gene inactivation and other aspects, but also of far-reaching significance in the diagnosis and treatment of tumors.

Meng Li. The involvement of mitochondrial proteins in tumorigenesis. Frontiers in Medical Science Research (2021) Vol. 3 Issue 5: 10-15. https://doi.org/10.25236/FMSR.2021.030502.

[1] Duchen M. R(2004).Mitochondria in health and disease: perspectives on a new mitochondrial biology. Molecular aspects of medicine,25(4).365-451.

[2] Abramov A. Y., Canevari L., Duchen M. R(2004).Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. The Journal of neuroscience: the official journal of the Society for Neuroscience, 24(2). 565-575.

[3] Boitier E., Rea R., Duchen M. R(1999).Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes. The Journal of cell biology, 145(4).795-808.

[4] Farrar G. J., Chadderton N., Kenna P. F., Millington-Ward S(2013).Mitochondrial disorders: aetiologies, models systems, and candidate therapies. Trends in genetics: TIG,29(8).488-497.

[5] Devic S(2016).Warburg Effect - a Consequence or the Cause of Carcinogenesis? Journal of Cancer, 7(7).817-822.

[6] Christofk H. R., Vander Heiden M. G., Harris M. H., Ramanathan A., Gerszten R. E., Wei R., Fleming M. D., Schreiber S. L., Cantley L. C(2008).The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature,452(7184).230-233.

[7] Schell J. C., Olson K. A., Jiang L., Hawkins A. J., Van Vranken J. G., Xie J., Egnatchik R. A., Earl E. G., DeBerardinis R. J., Rutter J(2014).A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth. Molecular cell, 56(3).400-413.

[8] Yang C., Ko B., Hensley C. T., Jiang L., Wasti A. T., Kim J., Sudderth J., Calvaruso M. A., Lumata L., Mitsche M., Rutter J., Merritt M. E., DeBerardinis R. J(2014).Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Molecular cell, 56(3).414-424.

[9] DeBerardinis R. J., Mancuso A., Daikhin E., Nissim I., Yudkoff M., and Wehrli S., Thompson C. B (2007) .Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proceedings of the National Academy of Sciences of the United States of America, 104(49).19345-19350.

[10] Stine Z. E., Walton Z. E., Altman B. J., Hsieh A. L., Dang C. V(2015).MYC, Metabolism, and Cancer. Cancer discovery, 5(10).1024-1039.

[11] Shroff E. H., Eberlin L. S., Dang V. M., Gouw A. M., Gabay M., Adam S. J., Bellovin D. I., Tran P. T., Philbrick W. M., Garcia-Ocana A., Casey S. C., Li Y., Dang C. V., Zare R. N., Felsher D. W(2015).MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. Proceedings of the National Academy of Sciences of the United States of America, 112(21).6539-6544.

[12] He Y., Hakvoort T. B., Kohler S. E., Vermeulen J. L., de Waart D. R., de Theije C., ten Have G. A., van Eijk H. M., Kunne C., Labruyere W. T., Houten S. M., Sokolovic M., Ruijter J. M., Deutz N. E., Lamers W. H (2010).Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. The Journal of biological chemistry, 285(13). 9516-9524.