OBJECTIVE: To investigate the efficacy and safety of Shengyang Yiwei Decoction as the main intervention in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), and to provide evidence for its clinical application. METHODS: Randomized controlled trials (RCTs) of Shengyang Yiwei Decoction in The treatment of IBS-D were searched from CNKI, Wanfang database, PubMed, The Cochrane Library and VIP database from the establishment of these databases to June 10, 2020. The Cochrane risk bias tool in the Cochrane manual was used to evaluate the literature quality. Meta-analysis was performed using RevMan5.3 software. Results: A total of 16 RCTs were included, involving 1244 patients. Meta-analysis results showed that: Total effective rate (N =1204, OR=3.38, 95%CI [2.43, 4.71], P < 0.00001), abdominal pain score after treatment (n= 444, MD=-0.25, 95%CI [-0.31, -0.19], P < 0.00001), diarrhea score after treatment (n=292, MD=-0.99, 95%CI [-1.25, -0.73], P < 0.00001), abdominal distension score after treatment (n=284, MD=-0.42, 95%CI [-0.54, -0.30], P < 0.00001) and stool traits score after treatment (n=348, MD=-0.40, 95%CI [-0.50, -0.30], P < 0.00001) were better than the control group. Conclusion: The experimental group is superior to the control group in improving clinical diagnosis and treatment efficiency and symptom score.

Tianshi Zhu, Hui Ding, Leilei Zheng. Meta-analysis of Shengyang Yiwei Decoction as The Main Intervention in The Treatment of Diarrhea-Predominant Irritable Bowel Syndrome. Frontiers in Medical Science Research (2021) Vol. 3 Issue 5: 37-44. https://doi.org/10.25236/FMSR.2021.030506.

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