Objective: To study the effects of potentilla anserina polysaccharide combined with aerobic exercise on blood lipid level and the liver in experimental hyperlipidemia rats. Methods: 50 healthy male wistar rats were selected after 5 days adaptive feeding. Rats were randomly divided into basic feeding group and high fat feeding group, which were divided into hyperlipidemia group (H group), hyperlipidemia + potentilla anserina polysaccharide group (P group), hyperlipidemia + aerobic group (E group), hyperlipidemia + potentilla anserina polysaccharide + aerobic group (PE group), 10 for each group, and basic feeding group were 10 for normal control group (C group). The feeding method of C group , H group and E group intragastrically  treated with normal saline (8ml/kg), P group and PE group with potentilla anserina polysaccharide at the dose of 100mg /( kg·d). Once a day, for 10 weeks . Group E and PE for platform sports, 16 m/min, the  slope is 0°, 15 min/d, increased the time every day to 60 min/d for a week at last. 5° in the second week, 60 min/d, 18 m/min, with the same running intensity amount to 50% maximum oxygen intake. Fifty healthy male wistar rats were selected after 5 days of adaptive feeding. Rats were randomly divided into basic feed and hyperlipidemia feed feeding, divided into hyperlipidemia (H group), hyperlipidemia + potentilla anserina polysaccharide (P group), hyperlipidemia + aerobic (E group), hyperlipidemia + potentilla anserina polysaccharide + (PE group), 10 each group and basic feed feeding in normal control (C). The feeding method provided C with gastric saline (8 ml/kg) and H, P and PE groups with potentilla anserina polysaccharide (8ml/kg, PAP solution of 100 mg/kg), once a day for 10 weeks. Group E and PE for rat platform training, 16 m/min, 0°, 15 min/d, per day, 5° in the second week, 60 min/d, 18 m/min, with the same running intensity and 50% maximum oxygen intake. Once a day, 6 days a week running as aerobic exercise, and test each indicator after 10 consecutive weeks. Measure the serum triglyceride (TG) , total cholesterol (TC ), low density lipoprotein(LDL) , high density lipoprotein (HDL), glutamate pyruvic transaminase (ALT),  glutamic oxaloacetic transaminase (AST), The malondialdehyde (MDA) and superoxidase dismutase (SOD),  levels of the liver tissue were measured. Results: Compared with the C group, extremely significantly differences in serum TC, LDL, ALT, SOD  in H, P, and E groups (p<0.01), extremely significantly differences in serum TG, HDL, AST and MDA in H group (p<0.01), significant difference in HDL in the P and E groups (p<0.01, p<0.05). However, there were no significant differences from each item in the PE group compared with C group (p>0.05). Compared with the H group, the serum TC, TG, LDL, HDL, ALT, SOD and MDA are very significant difference in C, H, P, E, and PE groups (p<0.01). Compared with the PE group, very significant differences in the serum TC, LDL and SOD in H, P, and E group (p<0.01). The serum TG, HDL, ALT, AST and MDA associated with the H group also has extremely significant differences compared with the PE group (p<0.01). The HDL associated with the E group, the AST in the P group, there were significant differences compared with the PE group (p <0.05). Conclusion: PAP, hyperlipidemia in rats with PAP and elevated SOD, has an obvious effect in reducing the symptoms of hyperlipidemia, but gastric PAP combined with aerobic exercise reduced the symptoms most significantly in hyperlipidemia rats, after 10 weeks of gastric PAP and aerobic exercise, hyperlipidemia rats compared with ordinary feed-fed control group, has the best effect p>0.05.

Fangcheng Li, Tiande Hou. Effects of Potentilla Anserina Polysaccharide Combined with Aerobic Exercise on Blood Lipid Level and the Liver in Experimental Hyperlipidemia Rats. Frontiers in Medical Science Research (2021) Vol. 3 Issue 6: 15-20. https://doi.org/10.25236/FMSR.2021.030604.

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