Yulan Li1, Feixue Xu1,*, Ling Yue2, Rui Su3
1,2,3 The First Clinical Medical College of Lanzhou University, Chengguan District,Lanzhou ,Gansu Province,730030,China
1,*The First Hospital of Lanzhou University,Lanzhou University, Chengguan District, Lanzhou, Gansu Province,730030, China
Cervical cancer is the most common gynecological malignancy in developing countries. Scholars at home and abroad call cervical cancer younger than 35 years old as cervical cancer in young women (referred to as young cervical cancer). In recent years, with the promotion of cervical cancer screening, the incidence of young cervical cancer has gradually increased. This case reports a 17-year-old teenager with stage IV cervical squamous cell carcinoma with human papillomavirus type 16 and 18 positive and abnormal lipid metabolism. The onset is early, the clinical symptoms are typical, the disease progresses rapidly, and the prognosis is poor. Review the patient’s family history, morbidity, sexual life history and related clinical examination indicators, and consult relevant literature to find factors related to the onset of cervical cancer, and summarize the characteristics of the case to improve clinicians’ awareness and clinical diagnosis of the disease, And at the same time discuss whether the initial screening age for special populations should be treated specially.
Young Women, Cervical Cancer, Human Papillomavirus Infections, Risk Factors, Abnormal Lipids Metabolism, Case Report
Yulan Li, Feixue Xu, Ling Yue, Rui Su. A case of premature onset of young cervical cancer with abnormal lipid metabolism and literature review. Frontiers in Medical Science Research (2021) Vol. 3 Issue 6: 70-75. https://doi.org/10.25236/FMSR.2021.030613.
 Zhang Guyu, Zhu Yiyun, Liu Chongdong, et al. (2018). Current status and future of targeted therapy for locally advanced cervical cancer. Chinese Journal of Practical Gynecology and Obstetrics, 11, 1216-1220.
 Ao Meihong, Deng Xuqing , Xiong Yan, et al.(2018).Analysis of the incidence trend of 7051 cases of cervical cancer[J].Progress in Modern Obstetrics and Gynecology,01,48-50.
 Yu Hui, Xu Jia, Wu Huan, et al. (2019). HPV infection status and follow-up analysis of women aged 20 and under in a hospital in Wuhan [J]. Journal of Huazhong University of Science and Technology (Medical Edition), 05,594-598.
 Yuan Fengling, Jia Shuhui, Jiang Yuan. (2020). Clinicopathological factors and prognosis analysis of 101 young patients with cervical cancer [J]. Journal of Practical Cancer, 12, 2058-2060.
 Qin Hongzhen. (2019). New progress in diagnosis and treatment of cervical cancer in young women [J]. Electronic Journal of Practical Gynecology and Endocrinology, 30, 10-11.
 Lili Qian, Yu Zhang, Dawei Cui, et al. (2017). Analysis of epidemiological trends in human papillomavirus infection among gynaecological outpatients in Hangzhou, China, 2011-2015[J]. BMC Infectious Diseases, 1.
 Hu Shangying, Zhao Xuelian, Zhang Yong, et al. (2021). Interpretation of "Prevention of Cervical Cancer: WHO Guidelines for Screening and Treatment of Cervical Precancerous Lesions (Second Edition)"[J]. Chinese Medical Journal, 34, 2653 -2657.
 Shang Xuejun, Xu Song. (2019). Human Papillomavirus and Male Reproductive Health [J]. Chinese Journal of Andrology, 01, 3-8.
 Elizabeth T. H. Fontham MPH, DrPH, Andrew M. D. Wolf MD, et al. (2020). Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society. CA: A Cancer Journal for Clinicians, 5.
 Zeng Guangqi, Zhao Hongfu. (2019). Discussion on changes of spouse's high-risk human papillomavirus infection before and after circumcision [J]. International Infectious Diseases (Electronic Edition), 03, 24-25.
 Huang Ying, Wang Aiming, Zhao Yong, et al. (2013). Research progress on the correlation between oral contraceptives and tumors [J]. China Maternal and Child Health Care, 17, 2833-2836.
 Li Jian, Fan Guangsheng, Xu Ling. (2015). Interpretation of clinical cognition of compound oral contraceptives [J]. Chinese Journal of Obstetrics and Gynecology, 01, 28-31.
 Liu Yanmei, Yang Qi, Wang Saisai, et al. (2020). Expression of HIF-1α and HIF-2α proteins in cervical cancer and their relationship with prognosis [J]. Zhejiang Medical Journal, 02,105-108.
 He Jiaoyu, Li Tianjun, Wang Youliang, et al. (2021). Genetic variability of human papillomavirus type 39 based on E6, E7 and L1 genes in Southwest China. Virology journal, 1.
 Liao Ling-Min, Sun Xiao-Ying, Liu, et al. (2014). Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer. Gynecologic oncology, 3.
 Yu Aijun, Zhang Jiejie, Mei Yuxian, et al. (2020). Correlation Between Single Nucleotide Polymorphisms of an miRNA Binding Site in the 3'UTR of PTEN and Risk of Cervical Cancer Among the Han Chinese. [J]. Genetic testing and molecular biomarkers, 7.
 Chen Xinghui, Li Changfang. (2018). Research progress on the correlation between blood lipid levels and cancer [J]. Medical Review, 18, 78-82.
 Yang Wei, Bai Yibing, Xiong Ying, et al. (2016). Potentiating the antitumour response of CD8 (+) T cells by modulating cholesterol metabolism. Nature, 7596.
 Suganami Eri, Takagi Hitoshi, Ohashi Hirokazu, et al. (2004). Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. Diabetes, 9.
 Nie Ming. (2016). Clinical expression and clinical value analysis of leptin in cervical cancer [J]. Electronic Journal of Clinical Medicine Literature, 24, 4894-4895.