Objective: To explore the relation between hs-CRP, IL-6 levels and cognitive function in depression sick persons co-morbid with type 2 diabetes. Methods: 200 sick persons with first-episode depression who were hospitalized at Kailuan Mental Health Center from May 2019 to May 2021 were selected. According to whether were co-morbid with type 2 diabetes, they were divided into 100 sick persons with depression co-morbid with type 2 diabetes (observation group) and 100 sick persons with depression alone (control group). The baseline data, HAMD-24 item scores, serum hs-CRP and IL-6 levels, cognitive function and the relation between hs-CRP and IL-6 and total MoCA score and each factor and total HAMD-24 score in the observation group were compared between the two groups, and the difference was considered statistically significant at P<0.05. Results: There was a statistical difference in the total HAMD-24 score between the 2 groups of sick persons (P<0.05). The serum hs-CRP and IL-6 levels of sick persons in the observation group were significantly higher than those in the control group (P<0.05). Delayed memory, abstract thinking, attention, memory, visuospatial ability, orientation scores and total MoCA scores were lower in the observation group than in the control group (P<0.05). There was a highly significant negative relation (P<0.01) between serum hs-CRP and IL-6 and delayed memory, attention, memory, visuospatial ability, and total MoCA score in the observation group; and a highly significant positive relation (P<0.01) with total HAMD score. Conclusion: Serum hs-CRP and IL-6 levels were higher in depression sick persons co-morbid with type 2 diabetes than in those with depression alone, and there was a relation between serum hs-CRP and IL-6 levels and depression levels as well as cognitive function.

Yusheng Han, Yi Xiao. Relation Analysis between IL-6 Levels and Cognitive Function in Depression Sick Persons Co-morbid with Type 2 Diabetes. Frontiers in Medical Science Research (2022) Vol. 4, Issue 2: 12-16. https://doi.org/10.25236/FMSR.2022.040203.

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