Objective: To evaluate the clinical efficacy and safety of Banxia Xiexin Decoction in the treatment of ulcerative colitis(UC). Methods: The Cochrane Library, PubMed, Embase, CBM, CNKI, VIP and Wanfang databases were searched by computer, and the clinical randomized controlled trials(RCTs) of Banxia Xiexin Decoction in the treatment of UC were included with the method of manual retrieval. The retrieval time was from the establishment of each database to March 16,2021. Meta-analysis was completed Rev Man 5.3. Results: This study included 16 articles,1332 patients. Meta-analysis showed that the total effective rate was [RR = 1.29, 95%CI:1.23~1.36,Z=9.82(P＜0.01)];The cure rate [RR=1.72,95%CI:1.43~2.06,Z=5.79(P＜0.01)];The incidence of adverse reactions was [RR=1.2 9,95%CI:0.27~0.65,Z=3.88(P=0.0001)];Symptom disappearance time ①Abdominal pain disappearance time: [MD =-4.45, 95%CI:-5.03~-3.86,Z=14.99(P＜0.01)],②Diarrhea disappearance time: [MD=- 2.7 0,95%CI:-3.27~-2.13, Z=9.28(P＜0.01)],③Skeptics tool disappearance time: [MD=-2.55, 9 5%CI:-3.09~-2.02,Z=9.32(P＜0.01)];The levels of inflammatory factors TNF -α and IL- 1①TNF -α: [MD=-5.3 6,95%CI:-7.70~-3.02,Z=4.49(P＜0.01)],②IL-1 :[MD =-0.41, 9 5%CI:-0.77~-0.06,Z=6.50(P =0.02)]; Conclusions: Curative Effect and Safety of Modified Banxia Xiexin Decoction on UC.

Yanan Ai, Yuqing Xu, Wen Wen, Yunhan Yin, Jintao Zhou, Weihan Zhao. A Meta-analysis of efficacy and safety of Banxia Xiexin decoction on ulcerative colitis. Frontiers in Medical Science Research (2022) Vol. 4, Issue 4: 26-35. https://doi.org/10.25236/FMSR.2022.040405.

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