Oxygen therapy has made great development in the fields of prevention, treatment, and rehabilitation of diseases, and its clinical application is also very extensive. It has been found that oxygen inhalation can treat a variety of brain diseases from various aspects such as blood, metabolism, and cells. In this paper, we will review the previous studies and propose future research ideas based on the potential mechanism of oxygen inhalation through brain structure and brain metabolism in the treatment of various brain diseases.

Meiyi Wang . Oxygenation and Brain Diseases. Frontiers in Medical Science Research (2022) Vol. 4, Issue 6: 8-11. https://doi.org/10.25236/FMSR.2022.040602.

[1] Aneesh, B. , Singhal, Eva, Ratai, Thomas, & Benner, et al. (2007). Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke. Stroke; a journal of cerebral circulation.

[2] Bachelot A, Gilleron J, Meduri G, et al. A common African variant of human connexin 37 is associated with Caucasian primary ovarian insufficiency and has a deleterious effect in vitro[J]. International Journal of Molecular Medicine, 2018.

[3] Choi, M. H., Kim, H. J., Chung, Y. S., & Chung, S. C. (2012). Effects of hyperoxic air on simple visual matching task performance and blood oxygen saturation of ADHD children. HealthMED, 6(9), 3008-3011.

[4] Kim, H. S., Choi, M. H., Baek, J. H., Park, S. J., Lee, J. C., Jeong, U. H., Kim, S. P., Kim, H. J., Choi, Y. C., Lim, D. W., & Chung, S. C. (2015). Effects of 92% oxygen administration on cognitive performance and physiological changes of intellectually and developmentally disabled people. Journal of Physiological Anthropology, 34(1). https://doi.org/10.1186/s40101-015-0043-9

[5] Moss, M. C., & Scholey, A. B. (1996). Oxygen administration enhances memory formation in healthy young adults. Psychopharmacology, 124(3), 255–260. https://doi.org/10.1007/bf02246665

[6] Prechtel M M,  Walenga J M . Emphasis on the Role of PF4 in the Incidence, Pathophysiology, and Treatment of Heparin-Induced Thrombocytopenia[J]. Thrombosis Journal, 2013, 11(1):7.

[7] Sigal T, Amir H,  Efrat S, et al. Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients[J]. Frontiers in Human Neuroscience, 2017, 11:508.

[8] Smyth S S, Iii D,  Wysokinski W E, et al. Platelet activation and its patient-specific consequences[J]. Thrombosis Research, 2008, 122(4):435-441.

[9] Tang X, Yin X, Tao Z, et al. The effect of hyperbaric oxygen on clinical outcome of patients after resection of meningiomas with conspicuous peritumoral brain edema.[J]. Undersea & Hyperbaric Medicine Journal of the Undersea & Hyperbaric Medical Society Inc, 2011, 38(2):109.

[10] Wang PF,  Zhou Y,  Fang H, et al. Treatment of acute cerebral ischemia using animal models: a meta-analysis[J]. Translational Neuroscience, 2015, 6(1).

[11] Wang, J., Gong, D., & Yao, D. (2021). Long Term Exposure to High Altitude Effects Behavioral Inhibitory Control. International Journal of Psychophysiology, 168, S230. 

[12] Yokote A,  Hashimoto K,  Bike R, et al. Elevated Release of Beta-thromboglobulin and Platelet Factor 4 in Cerebral Infarction Patients with Branch Atheromatous Disease: A Preliminary Report[J]. Neurologia medico-chirurgica, 2015, 55(10):809-812.

[13] Zhai W W,  Liang S,  Yu Z Q, et al. Hyperbaric oxygen therapy in experimental and clinical stroke[J]. Medical Gas Research, 2016, 6(2).

[14] Zhao H,  Zhang Q,  Xue Y, et al. Effects of hyperbaric oxygen on the expression of claudins after cerebral ischemia-reperfusion in rats[J]. Experimental Brain Research, 2011, 212(1):109-117.