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Frontiers in Medical Science Research, 2022, 4(9); doi: 10.25236/FMSR.2022.040905.

Design, synthesis and study of novel indoxine derivatives

Author(s)

Haiyang Sun1, Lei Lv1, Hanchi Liu2, Haiyu Pan1

Corresponding Author:
Haiyu Pan
Affiliation(s)

1School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, 063210, China

2School of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, Hebei, 063210, China

Abstract

Keeping in view the pharmacological properties of indolinones as promising scaffold as kinase inhibitors, herein, a novel series of N- benzyl-4-phenyl-5-cyano-indoxine moiety were synthesized, studied by molecular docking, and fully characterized by spectroscopic techniques. All the prepared compounds were evaluated for their cytotoxicity attributes against a panel of tumor cell lines, including cardiovascular disease (ALA-564). They displayed moderate to promising antiproliferative effects toward ALA-564. The molecular docking studies demonstrated that our prepared compounds were potentially bound to 4UWC active site through essential H-bond and other vital interactions with critical binding residues.

Keywords

Cardiovascular disease, indolizine, 4UWC

Cite This Paper

Haiyang Sun, Lei Lv, Hanchi Liu, Haiyu Pan. Design, synthesis and study of novel indoxine derivatives. Frontiers in Medical Science Research (2022) Vol. 4, Issue 9:23-29. https://doi.org/10.25236/FMSR.2022.040905.

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