Welcome to Francis Academic Press

Frontiers in Medical Science Research, 2022, 4(9); doi: 10.25236/FMSR.2022.040906.

Research Progress of PRP and Chinese Medicine in the Treatment of Knee Osteoarthritis

Author(s)

Shouguo Wang1, Wenxian Zhang2, Xiaoqiang Wang1, Shijie Wang1, Jianwei Zhao1, Qikai Yan1

Corresponding Author:
Wenxian Zhang
Affiliation(s)

1Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, China

2Gansu Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, China

Abstract

Knee osteoarthritis is a common and frequently occurring disease in clinic, and degeneration of articular cartilage is one of the main causes of this disease. Delaying cartilage degeneration and promoting cartilage repair are important ways to relieve pain and improve function. PRP is an autologous product derived from highly centrifugal blood, which contains a high concentration of effective factors, which can maintain tissue homeostasis and regulate the body's inflammation and coagulation. The product can regulate bone and blood vessel remodeling, inhibit chondrocyte apoptosis, inhibit inflammatory reaction and promote collagen synthesis by injection into the joint. PRP has unique advantages in the treatment of knee osteoarthritis, and has become one of the feasible methods for clinical treatment of KOA. Based on this, through this review, the author will elaborate the preparation of PRP, the mechanism of ACTION of KOA, the safety evaluation, the advantages of PRP and other treatment methods, and the combination of PRP and TRADITIONAL Chinese medicine in the treatment of knee osteoarthritis, aiming to provide new ideas, new methods and new methods for clinical diagnosis and treatment.

Keywords

Knee osteoarthritis, PRP, Mechanism of action

Cite This Paper

Shouguo Wang, Wenxian Zhang, Xiaoqiang Wang, Shijie Wang, Jianwei Zhao, Qikai Yan. Research Progress of PRP and Chinese Medicine in the Treatment of Knee Osteoarthritis. Frontiers in Medical Science Research (2022) Vol. 4, Issue 9:30-35. https://doi.org/10.25236/FMSR.2022.040906.

References

[1] ZHANG Bo, ZHANG Yafeng, WANG Hong, et al. Clinical value of pFO osteotomy in patients with medial pain knee osteoarthritis [J]. Chinese Journal of Gerontology, 2021, 41(16): 3440-3443.

[2] MENG Hongsen, Zuo Xiuqin, WANG Ning, et al. Treatment of knee osteoarthritis with platelet-rich plasma [J]. Chinese Journal of Bone and Joint Injury, 2021, 36(8): 894-896.

[3] Ayhan E,Kesmezacar H,Akgun I. Intraarticular Injections(corticosteroid, Hyaluronic Acid, Platelet Rich Plasma) for the Knee Osteoarthritis[J]. World Journal of Orthopedics, 2014, 5(3): 351-361.

[4] Jin Weiming, Chen Senlin, LI Wei, et al. Clinical study on the relationship between DTI parameters of high cervical spinal cord and Hoffman's sign in CSM patients [J]. Journal of Anhui Medical University, 2021(12): 1970-1975.

[5] Zhao J,Huang H,Liang G, et al. Effects and Safety of the Combination of Platelet-rich Plasma (prp) and Hyaluronic Acid (ha) in the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis[J]. Bmc Musculoskeletal Disorders, 2020, 21(6).

[6] WANG Yangfa, LIU Jun, PAN Jianke, et al. Efficacy of platelet rich plasma and hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(27): 4421-4428.

[7] Kanchanatawan W,Arirachakaran A,Chaijenkij K, et al. Short-term Outcomes of Platelet-rich Plasma Injection for Treatment of Osteoarthritis of the Knee[J]. Knee Surgery, Sports Traumatology, Arthroscopy, 2016, 24(5).

[8] Patil S,Mccauley JC,Pulido P, et al. How Do Knee Implants Perform Past the Second Decade? Nineteen- to 25-year Followup of the Press-fit Condylar Design Tka[J]. Clinical Orthopaedics and Related Research, 2015, 473(1).

[9] Yin Zhenglu, MENG Zhaoxiang, WANG Jibing, et al. Effects of intraarticular injection of Platelet-rich plasma or Sodium hyaluronate combined with isokinetic muscle training on knee osteoarthritis [J]. Chinese Journal of Physical Medicine and Rehabilitation, 2019, 41(10): 764-765.

[10] SU Xianliang, Lou Qiuhua, QIN Fangyuan, et al. Chinese Journal of Orthopaedic Surgery, 2021, 29(17): 1601-1604.

[11] Wu Xiao, TAN Yajun, Xian Jie, et al. Repair of knee osteoarthritis with platelet-rich plasma [J]. Chinese Journal of Tissue Engineering Research, 2016, 20(42): 6259-6264.

[12] Chen Ziming,Deng Zhantao,Ma Yuanchen,. Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis. [Z], 2019.

[13] Xiang Renxue, Wu Jianjun, Wang Jiajia, et al. Quality of platelet-rich plasma prepared by manual and automatic method and curative effect analysis of knee joint diseases [J]. Chinese Journal of Blood Transfusion, 2021, 34(7): 695-698.

[14] Shan Guiqiu, SHI Linying, Li Yanhui, et al. Chinese Journal of Blood Transfusion, 2021, 34(7): 677-683.

[15] Bocun L,Jing L,Jia L, et al. Effects of Platelet-rich Plasma Injection for Pain Control and Cartilage Repair in Knee Osteoarthritis: a Protocol for the Systematic Review and Meta-analysis of Randomized Controlled Trials in Animal Models.[J]. Medicine (baltimore), 2021, 100(1): 0.

[16] Szwedowski D, Szczepanek J, Paczesny , et al. The Effect of Platelet-rich Plasma on the Intra-articular Microenvironment in Knee Osteoarthritis. [J]. Int J Mol Sci, 2021, 22(11).

[17] Edwards Sara-L,Lynch T-Sean,Saltzman Matthew-D. Biologic and pharmacologic augmentation of rotator cuff repairs. [Z], 2011: 9-583.

[18] Creaney L,Hamilton B. Growth factor delivery methods in the management of sports injuries: the state of play.[Z], 2007: 20-314.

[19] Gholami M,Ravaghi H,Salehi M, et al. A Systematic Review and Meta-analysis of the Application of Platelet Rich Plasma in Sports Medicine. [J]. Electron Physician, 2016, 8(5): 32-2325.

[20] Taylor D W, Petrera M, Hendry M. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries.[J]. Clinical Journal of Sport Medicine Official Journal of the Canadian Academy of Sport Medicine, 2011, 21(4):344.

[21] Cicha Iwona,Garlichs Christoph-D,Daniel Werner-G. Activated human platelets release connective tissue growth factor. [Z], 2004: 60-755.

[22] Halpern BC,Chaudhury S,Rodeo SA. The Role of Platelet-rich Plasma in Inducing Musculoskeletal Tissue Healing. [J]. Hss J, 2012, 8(2): 45-137.

[23] Lars, Engebretsen. The Use of Platelet-Rich Plasma in Sports Medicine—the International Olympic Committee Opinion[J]. Operative Techniques in Orthopaedics, 2012.

[24] Lopez-castejon Gloria,Brough David. Understanding the mechanism of IL-1β secretion. [Z], 2011: 95-189.

[25] Baht GS,Vi L,Alman BA. The Role of the Immune Cells in Fracture Healing. [J]. Curr Osteoporos Rep, 2018, 16(2): 138-145.

[26] Navarro-sarabia F,Coronel P,Collantes E, et al. A 40-month Multicentre, Randomised Placebo-controlled Study to Assess the Efficacy and Carry-over Effect of Repeated Intra-articular Injections of Hyaluronic Acid in Knee Osteoarthritis: the Amelia Project[J]. Crossref, 2011, 70(11): 1957-1962.

[27] Annaniemi JA,Pere J,Giordano S. Platelet-rich Plasma Versus Hyaluronic Acid Injections for Knee Osteoarthritis: a Propensity-score Analysis[J]. Crossref, 2018, 108(4): 329-337.

[28] He Cuihuan. Clinical observation of platelet rich plasma combined with Xianling Gubao capsule in the treatment of KOA and network pharmacology [D]. Guangzhou University of Chinese Medicine, 2019.

[29] Babaei-ghazani A,Najarzadeh S,Mansoori K, et al. The Effects of Ultrasound-guided Corticosteroid Injection Compared to Oxygen–ozone (o2–o3) Injection in Patients with Knee Osteoarthritis: a Randomized Controlled Trial[J]. Crossref, 2018, 37(9): 2517-2527.

[30] Jesus CCLD. Comparison Between Intraarticular Ozone and Placebo in the Treatment of Knee Arthritis[Z]: Springer Science and Business Media Llc, 2012.

[31] Duymus TM,Mutlu S,Dernek B, et al. Choice of Intra-articular Injection in Treatment of Knee Osteoarthritis: Platelet-rich Plasma, Hyaluronic Acid Or Ozone Options[J]. Crossref, 2016, 25(2): 485-492.

[32] Huang Y,Liu X,Xu X, et al. Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid Or Corticosteroids for Knee Osteoarthritis[J]. Crossref, 2019, 48(3): 239-247.

[33] Bao X,Tan J,Flyzik M, et al. Effect of Therapeutic Exercise on Knee Osteoarthritis After Intra-articular Injection of Botulinum Toxin Type A, Hyaluronate Or Saline: a Randomized Controlled Trial[J]. Crossref, 2018, 50(6): 534-541.

[34] Li W,Pan J,Lu Z, et al. The Application of Platelet-rich Plasma in the Treatment of Knee Osteoarthritis: A Literature Review. [J]. J Orthop Sci, 2021.

[35] Yang Chen. Efficacy of gubi Zhitong Fluid combined with PRP in treatment of knee osteoarthritis (liver and kidney deficiency type) [D]. Gansu University of Traditional Chinese Medicine, 2021.

[36] Lam,Yee, Ching. Clinical efficacy and literature metrology study of platelet-rich plasma combined with Xieling Gubao capsule in the treatment of knee osteoarthritis [D]. Guangzhou University of Chinese Medicine, 2019.

[37] Xia Tao, Wang Qinfeng. Research on the application value of seamless nursing management mode in the management of external instruments in operating room [J]. Chinese Journal of Medical Innovation, 2021, 18(31): 112-115.