Frontiers in Medical Science Research, 2022, 4(9); doi: 10.25236/FMSR.2022.040908.
Suwei Lan1, Xingcha Wang1, Penghua Cui1, Chunhui Wang1, Mingjing Zhai1, Yang Li2, Lifeng Chang1
1Department of Gynecology, Affiliated Hospital of Chengde Medical College, Chengde, Hebei, China
2Department of Pediatrics, Chengde Maternal and Child Health Center, Chengde, Hebei, China
3Department of Obstetrics and Gynecology, Pingquan Hospital, Chengde, Hebei, China
To investigate the changes of ovarian reserve function in real-world of patients diagnosed endometriosis with different stages, preoperative and postoperative, respectively. Ananlysis the relationship between anti-mullerian hormone (AMH) and CA125. A total of 50 patients operatived because of uterine myoma and 185 patients diagnosed endometriosis from 2014 to June 2020 were inrolled. Of the endometriosis patients, 70 patients with stage Ⅰ-Ⅱ and 115 patients with stage Ⅲ-Ⅳ. The groups were redivided into group A(≤35years) and group B (>36) based on age. The serum CA125 and AMH was tested preoperative, retested the AMH1 and 6 months postoperaive. Then analyzed these data by statistical methods. ① There is no statistical significance in the same age groups versus preoperative blood AMH in patients with Ⅰ-Ⅱ stage endometriosis groups and in the myoma patients (P> 0.05), compared to the Ⅲ-Ⅳ stage of endometriosis, the AMH were high in the myoma groups and Ⅰ-Ⅱ stage endometriosis groups (P <0.05); ② There was no significantly change of serum AMH in the uterine myoma groups between preoperative and postoperative, the differental has no statistical significance (P>0.05)in the Ⅰ-Ⅱ stage endometriosis a groups, the AMH decreased 1 month after operation, whereas there was no significant decrease 6 months after operation compared to preoperative, and the difference had not statistically significance (P> 0.05). In the Ⅲ-Ⅳ stage endometriosis groups, the AMH decreased after operation in 1 and 6 months, and the difference had statistically significance (P <0.05). ③ The CA125 was significantly higher in advanced endometriosis stages compared to the Ⅰ-Ⅱ stage groups and uterine myoma groups, and was negatively correlated with preoperative AMH.
Anti-mullerian hormone; Ovarian endometriosis cyst; CA125; Ovarian reserve function
Suwei Lan, Xingcha Wang, Penghua Cui, Chunhui Wang, Mingjing Zhai, Yang Li, Lifeng Chang. A Real-world Study of Changes in Preoperative and Postoperative CA125, A and M H in Patients with Endometriosis. Frontiers in Medical Science Research (2022) Vol. 4, Issue 9:41-46. https://doi.org/10.25236/FMSR.2022.040908.
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