Alzheimer's disease (AD) is the most common form of dementia, with patients initially experiencing mild memory impairment and then progressive cognitive loss, causing significant stress to families and society. As the number of patients continues to increase, it is important to explore a variety of treatment options. In recent years, non-pharmacological treatments have played a significant role in the prevention and relief of AD. Among them, exercise therapy has become one of the ideal options for non-pharmacological interventions as it can improve cognition and reduce neuropsychiatric symptoms in AD patients. In this paper, the effects and mechanisms of exercise therapy on the cognitive function of AD patients are reviewed in the hope of providing clinical practitioners with some assistance in the treatment and rehabilitation of AD.

Yang Song, Li Maoquan. Effects of exercise therapy on cognitive function in Alzheimer's disease and mechanisms of action. Frontiers in Medical Science Research (2022) Vol. 4, Issue 10: 18-22. https://doi.org/10.25236/FMSR.2022.041004.

[1] De la Rosa A, Olaso-Gonzalez G, Arc-Chagnaud C, Millan F, Salvador-Pascual A, García-Lucerga C, Blasco-Lafarga C, Garcia-Dominguez E, Carretero A, Correas AG, Viña J, Gomez-Cabrera MC. Physical exercise in the prevention and treatment of Alzheimer's disease. J Sport Health Sci. 2020 Sep;9(5):394-404. 

[2] Smith BC, D'Amico M. Sensory-Based Interventions for Adults with Dementia and Alzheimer's Disease: A Scoping Review. Occup Ther Health Care. 2020 Jul;34(3):171-201. doi: 10.1080/07380577.2019.1608488. Epub 2019 May 8. 

[3] Garrido S, Dunne L, Chang E,et al. The Use of Music Playlists for People with Dementia: A Critical Synthesis. J Alzheimers Dis. 2017;60(3):1129-1142. doi: 10.3233/JAD-170612. 

[4] Singh SK, Srivastav S, Yadav AK, Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds. Oxid Med Cell Longev. 2016; 2016:7361613. 

[5] Singh SK, Srivastav S, Yadav AK,et al. Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds. Oxid Med Cell Longev. 2016; 2016:7361613. 

[6] Metaxas A., Kempf S.J. Neurofibrillary tangles in Alzheimer’s disease: Elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics. Neural Regen. Res. 2016;11:1579–1581. doi: 10.4103/1673-5374.193234. 

[7] Spires-Jones T. L., and Hyman B. T. (2014) The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron 82, 756–771

[8] Laver K, Dyer S, Whitehead C,et al. Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews. BMJ Open. 2016; 6(4): e010767.

[9] Stojanovic M, Jin Y, Fagan AM,et al. Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning. Alzheimer Dis Assoc Disord. 2020 Jul-Sep; 34(3):212-219. 

[10] Xu Q, Zhao ZL, Wang X. A meta-analysis of the effect of aerobic exercise on cognitive function intervention in patients with Alzheimer's disease[J]. Chinese Journal of Rehabilitation Medicine, 2019,34(07):824-830. 

[11] Lima BN, Lucareli PR, Gomes WA, Silva JJ,, et al. (2014) The acute effects of unilateral ankle plantar flexors static- stretching on postural sway and gastrocnemius muscle activity during single-leg balance tasks. J Sports Sci Med 13:564–570. 

[12] Neeper S. A., Gómez-Pinilla F., Choi J.et al. Exercise and brain neurotrophins. Nature. 1995; 373(6510):p. 109. doi: 10.1038/373109a0.

[13] Lv Huanyu,Shang Ziqi,Mao Yifan et al. Research progress on the effects of exercise and diet on FNDC5 and BDNF[J]. Science and Technology Information, 2021,19(05):252-256.

[14] Burdette Jonathan H, Laurienti Paul J, Espeland Mark A, et al. Using network science to evaluate exercise-associated brain changes in older adults.[J]. Frontiers in Aging Neuroscience, 2010, 2:23.

[15] Liu-Ambrose T,Nagamatsu LS,Voss MW,et al. Resistance training and functional plasticity of the aging brain:a 12-month randomized controlled trial[J]. Neurobiol Aging, 2012(8):1690~1698.

[16] Gao J, Li F, Zhao P. A comprehensive training method for 150 patients with post-stroke cognitive impairment [J]. Evaluation of the effect of integrated training method for 150 patients with cognitive impairment after stroke[J]. Chinese convalescent medicine, 2015, 24(05):505-507. DOI: 10.13517/j. cnki.ccm.2015.05.029  

[17] Chen YM,Ding XC,Liu H et al. A study on the intervention effect of cognitive training on cognitive function of older adults in the community[J]. Shanghai Preventive Medicine, 2016,28(10):728731. DOI:10.19428/j.cnki.sjpm.2016.10.013  

[18] Zhu ZD. Mechanisms of neuroplasticity in cognitive training to improve cognitive function in patients with vascular mild cognitive impairment[A]. Chinese Psychological Society. Abstracts of the 22nd National Psychology Conference [C]. Chinese Psychological Society: Chinese Psychological Society, 2019:1.

[19] Sun Xiaohui,Xing Qiuyan,Li Xuejie. The effect of comprehensive cognitive training on cognitive function of elderly people with mild cognitive impairment in nursing homes[J]. Modern medicine and health, 2018,34(04):526-528.

[20] Chen K,Zhang Xianliang,Du Litao. Exercise enhances silent information regulator 2-related enzyme 1 to improve Alzheimer's disease[J/OL]. Chinese Journal of Biochemistry and Molecular Biology, 2022, 38(5):7.

[21] Zhang YT. Notch1 signaling pathway-mediated aerobic exercise modulates AHN to improve learning memory in AD mice [D]. Chengdu Institute of Physical Education, 2021.

[22] Sun, R. F., Gong, W. J.. Research on motor intervention strategies in the field of cognitive rehabilitation [J]. Neurological Injury and Functional Reconstruction, 2021,16(08):469-471.

[23] Bettio L, Thacker JS, Hutton C, et al. Modulation of synaptic plasticity by exercise[J]. Int Rev Neurobiol, 2019, 147: 295-322. 

[24] Deng Yuting,Ma Chunlian,Yang Y. Irisin: a new target for exercise to improve synaptic plasticity to alleviate cognitive decline in Alzheimer's disease[J]. Chinese Sports Science and Technology, 2020,56(9):30-36.

[25] Liu Z M. Effects of 4-week exercise and energy intake restriction on fat loss and Irisin in obese rats[D]. Beijing University of Sports,2019.

[26] Zhang N, Wang Lizhi, Yang Guijiao, et al. Effects of autonomous running wheel exercise on cognition, mood, and amygdala inflammatory factor expression in mice with Alzheimer's disease model[J]. Journal of Neuroanatomy, 2017,33(06):741-747.

[27] Li RD,Sun XY, Yan YB, et al. Effects of intensive training on cognitive impairment in Alzheimer's disease mice through modulation of hippocampal proteasome activity[J]. Journal of Clinical and Experimental Medicine, 2021,20(06):575-57