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Frontiers in Medical Science Research, 2022, 4(11); doi: 10.25236/FMSR.2022.041109..

Study on the polarization pathways of macrophages and related diseases


Lisha Ma1,2, Shangyi Lv1,2, Huiyu He1,2

Corresponding Author:
Huiyu He

1Department of Prosthodontics and Dental Implantology, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, Xinjiang 830054, China

2Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, Xinjiang 830054, China


Macrophage is a relatively stable heterogeneous immune cell isolated from monocytes in plasma, which plays a certain role in maintaining stable environment, host defense, phagocytosis and immune information transmission. Under the influence of different environmental factors, macrophages can be polarized into Ml and M2, and this process is reversible. The special phenotype of macrophage polarization can play a role in alleviating or curing the disease, and the polarization process is affected by the stimulation of different signaling pathways [1]. This chapter will review the classical types of macropage polarization, the most important information pathways and regulatory mechanisms, in an attempt to provide a basis for subsequent regulation and the occurrence and progression of lesions.


Macrophage polarization, Classical activation, Vicarious activation, Signaling pathways

Cite This Paper

Lisha Ma, Shangyi Lv, Huiyu He. Study on the polarization pathways of macrophages and related diseases. Frontiers in Medical Science Research (2022) Vol. 4, Issue 11: 53-60. https://doi.org/10.25236/FMSR.2022.041109.


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