Pinellia ternata has a clear nature, taste and channel, and is widely used in clinical practice. It is mainly used for various diseases caused by phlegm drinking. It is one of the commonly used Chinese herbal medicines by clinical doctors in ancient and modern times. Although ancient doctors have rich records on the compatibility application principles and related medicine of Pinellia ternata, today, when traditional Chinese medicine is modernized, there is a lack of effective sorting out of the pharmacological effects of Pinellia ternata compatibility on medicine.Through searching and sorting out the dictionary of traditional Chinese medicine prescriptions, this paper found that Pinellia ternata has obvious effects on anticoagulation, anti inflammation, anti-tumor, anti early pregnancy, sedation and hypnosis, and restricting toxicity It can be seen that it is of great significance to clarify the pharmacological action mechanism and detoxification mechanism of Chinese medicine compatibility for clinical prescriptions.

Li Ang, Cao Lanxiu. Research Progress on the Efficacy and Compatibility of Pinellia Ternata. Frontiers in Medical Science Research (2022) Vol. 4, Issue 12: 28-34. https://doi.org/10.25236/FMSR.2022.041205.

[1] National Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China: a volume [M]. China Medical and Technology Press, 2015:119-120.

[2] Shen Liansheng. Color Atlas of Shennong Materia medica [M]. Beijing: China Traditional Chinese Medicine Press. (in Chinese).1996.5:476.

[3] Ke Qin, Typhoid LAisuji. [M]. Beijing: China Traditional Chinese Medicine Publishing House. 2008.:144,171,201.

[4] Jin Jue, Xu Zihang, Chen Xiao. Evolution of Prescription syndrome of Banxia Shu Mi Tang in Successive Dynasties [J]. Journal of Beijing University of Traditional Chinese Medicine, 2018,41(09):726-730.

[5] Mao Qifen, Liu Yihong Jin Hang etc. Isolation and antimicrobial activity screening of endophytic seedlings of Pinellia ternata [J]. Chinese Journal of Traditional Chinese Medicine, 2014,32(8):1838 1841.

[6] Li Yikui, Pharmacology of Traditional Chinese Medicine [M]. Beijing: China Traditional Chinese Medicine Press.1992:157.

[7] Huang Qingzhang. Antitussive effect of Chinese medicine on Pinellia ternata and Fritillaria fritillaria. Chinese Journal of Traditional Chinese Medicine. 1954(5):325.

[8] Feng L, Yang J H, Experimental study on antitussive effect of Pinellia ternata from two different habitats in Guizhou Province [J]. Chinese Journal of Veterinary Medicine, 2015.(9):16-17.

[9] Zeng Song, Li Shuyuan, Wu Zhijian, et al. The antitussive and expectorant components of Pinellia pinellia. Study on effect Relationship [J]. Chinese Modern Traditional Medicine, 2013,15(6):452-455.

[10] Yang B Y, LI M, WU F F, Study on the method of evaluating the quality of Pinellia ternata and processed products based on cough titer [J]. Traditional Chinese medicine, 2015,46(17):2586-2592.

[11] Ke C Y, Study on expectorant and antitussive effects of five different solvent extracts from Pinellia ternata in mice [J]. Chinese Pharmacy, 2012,23(39):3652-3654.

[12] Zhang M F, Shen Y Q, ZHU Z P, et al. Research on the properties of Xinwen (Heat) combined with Spleen and stomach meridian Traditional Chinese medicine (ⅱ) on anti-ulcer effect [J]. Chinese medicine pharmacology and Clinic,1997,13,(4):1-4.

[13] Wu H, TANG Z J, Ye D J, et al. Comparison of composition contents and effects on animals of Pinellia pinellia by "orthogonal method" and pharmacopoeia method [J]. Chinese Journal of Traditional Chinese Medicine, 1999,24(1):25-28.

[14] Wang L, Zhao Y J, Zhang X N, et al. Determination of alkaloid content and antiemesis of Pinellia ternata [J]. Chinese Bulletin of Pharmacology,2005,521 (7) :864-867.

[15] Wang Guangde, Yang Xudong. pharmacology of Pinellia pinellia [J]. Foreign Medicine: Chinese Medicine and Chinese Materia Medica, 1985, 7 (5) :24-25.

[16] Jiang Wenyue, Yang Zi, Li Yanyan. effect of Pinellia ternata, Gua-wei, Fritillaria chinensis and Shiju Pu on hemorrheology in rats [J]. Journal of Traditional Chinese Medicine,2002. 43 (3) :215-216.

[17] Zhang M F, SHEN Y Q, Research progress in antibacterial, anti-inflammatory and antitumor effects of Rhizoma pinelliae [J]. Antiinfective pharmacy,2017,14 {6): 1089-1094.

[18] Xia Linna Li Chaojing, Antifertility effect of Pinellia protein on mice and mechanism of antipregnancy [J]. Journal of Shanghai First Medical College,1985,12 (3):193.

[19] Zhang M F, Shen Y Q, Research progress on toxicity and pharmacological action of Pinellia ternata extract against early pregnancy [J]. Antiinfective pharmacy, 2017,14(07).

[20] Zhu Funan, Zhou Yingjie. Experimental Study on the Eye-stimulating effect of Banxia Decoction in Neijing [J]. Journal of Chinese Academy of Sciences, 1990,10(3):202-204.

[21] Yu H L, Wu H, Zhang X D, et al. Stabilization of the irritant toxicity of Pinellia ternata and its needle crystal [J]. Traditional Chinese medicine 2010,33(6):903.

[22] Zhao Tengfei, Study on the toxicity mechanism of Pinellia pinellia and the treatment of Pinellia pinellia by ginger [D]. Master thesis of Nanjing University of Chinese Medicine, 2013.

[23] Zhang L M, Bao Z Y, Huang Y Y, et al. "Dose-time-toxicity" relationship of water extracts of Pinellia ternata on hepatic toxicity in mice [D]. Chinese pharmacovigilance, 2011,8(1):111.

[24] Yan Xiaoying, Chen Jupeng, Dong Ju, et al. Toxicity study on the decoction of raw Pinellia ternate [J]. Traditional Chinese Medicine Information, 2012, 29 (1): 102-105.

[25] Zhang Y, Shan J J, Xu J Y, et al. Research progress and new ideas on pregnancy toxicity of Pinellia ternata [J]. Chinese Journal of Traditional Chinese Medicine, 2016,3(3):938.

[26] Shen S F, Shan J J, Jin J, Et al. Toxicity mechanism of Pinellia pinellia and Pinellia pinellia on Beo cells based on metabonomic method [D]. Journal of Nanjing University of Traditional Chinese Medicine,2017,33(3):295.

[27] Yang Shouye, Wang Laisu. Banxia toxicity to pregnancy and embryo in rats [D]. Chinese Journal of Integrated Traditional and Western Medicine, 1989,9(8):481.

[28] Lee Seo Young et al. Proteome changes related to the anti-cancer activity of HT29 cells by the treatment of ginsenoside Rd.[J]. Die Pharmazie, 2009, 64(4) : 242-7.

[29] Son Keum-Joo et al. Immunogenic Cell Death Induced by Ginsenoside Rg3: Significance in Dendritic Cell-based Anti-tumor Immunotherapy.[J]. Immune network, 2016, 16(1): 75-84.

[30] CAI H L, Experimental study on toxicity of dried ginger and ginseng Pinellia decoction to mice during teratogenic sensitive period [D]. Yunnan University of Traditional Chinese Medicine2014 : 2.

[31] Mao W L, Chen Shu, Xu L Y etal. Preliminary study on quality Standard of Rhizoma arginis decoction pieces [J]. Chinese Herbal Medicine,1988,19(12):16-18.

[32] Duan Huiping, Hou Anji, Lu Fuer, Huang Jiule. Effect of carboxymethyl Tuckahoe polysaccharide on expression function of HBV transfected cells [J]. Chinese Journal of Experimental and Clinical Virology, 2005(03):290-292.

[33] Chen Chunxia. Liver protection and hypnotic effect of carboxymethyl Poria cocos polysaccharide [J]. Edible fungi,2003(S1):46-47.

[34] Liu X Q. Study on the mechanism of effect of huatan Jiangzhuo Prescription and its removal on phlegm and turbidity syndrome of hyperlipidemia in rats [D]. Guangzhou University of Chinese Medicine, 2018.

[35] Lin H M, Lu K N, Zhao K H, et al. Clinical study of Huatan Tongmai Decoction combined with metformin in the treatment of obesity polycystic ovary syndrome [J]. Liaoning Journal of Traditional Chinese Medicine, 2017,44(07):14-16.

[36] Lu Kina, Lin Hanmei, Huang Wei, Li Shanxia, Luo Naxin, Ban Sheng. Effect of "Pinellia -Angelica" on polycystic ovary syndrome based on network pharmacology [J]. Shi Zhen Chinese medicine,2019,30(03):539-543.

[37] Lim Y, and Kumar S. A single cut to pyroptosis.[J]. Oncotarget, 2015, 6(35) : 36926-7.

[38] Jin Y P. Detoxification mechanism of gingerol compounds from ginger against Pinellia pinellia and Pinellia palmata [D]. Nanjing University of Chinese Medicine,2016.

[39] Yi Quan, Tan Fanghui, Chen Weidong, Li Weida, Zhang Guiping, Zhang Genshui. Protective effects of honokiol and Magnolol on myocardial ischemia reperfusion injury in rats [J]. Guangdong Medical Journal, 2017,38(15):2276-2279.

[40] Xie N, Hu C Y, Wang X J, et al. Regulation of magnolol on hepatic X receptor α -mediated lipid metabolism [J]. Journal of Clinical Cardiovascular Disease,2015,31(09):1010-1013.

[41] Wang Liwen, Xie Mengyan, Lin Lili. Effect of magnolol on the apoptosis of pancreatic cancer cells induced by gemcitabine [J]. Chinese Journal of Clinical Pharmacology,2016,32(11):1027-1030.

[42] Xia Xichao, Hua Chunxiu, Jiang Xiao, Gui Gaixia, Wu Hongfang. Study on antioxidant effect of Magnolol and Honokiol on acute liver injury model mice [J]. Shi Zhen Chinese medicine, 2013, 24(02):361-362.

[43] Zhou Pingsheng, ZHa Qinglin, Wu Jiangfeng, Cheng Shiping. Analysis of compatibility application of Pinellia chinensis based on Data Mining [J]. Jiangxi Traditional Chinese Medicine, 2021,52(09):41-44.