Previous studies on oxygen intervention in high altitude environment mainly emphasize on the improvement effect of oxygen intervention on acute and chronic plateau diseases and various diseases, but there are fewer studies on the improvement of cognitive function of wholesome plateau people by oxygen intervention. This paper will further review the effect of oxygen intervention on cognitive function at high altitude from the application of oxygen intervention in high altitude environment, and explore its inner mechanism, which will provide new aspects for future research and have practical guidance significance for healthy life of plateau people.

Yuming Zhang, Chenxiao Han. Effect of the Oxygen Intervention on Cognitive Function at High Altitude and Mechanism of Action. Frontiers in Medical Science Research (2022) Vol. 4, Issue 12: 41-45. https://doi.org/10.25236/FMSR.2022.041207.

[1] Yang S.Y., Feng E.Z., Yan Z.Q., Zhang E., He W., & Tian Z.X., et al. (2012). Hypoxia and Tumor Necrosis Factor System Activity in Chronic Obstructive Pulmonary Disease Combined with Chronic Pulmonary Heart Disease in Highlands and the Impact on Malnutrition. Chinese Journal of Lung Diseases (electronic version) (03), 17-21.

[2] Wu, T.I.. (2012). Recent advances in the study of chronic plateau diseases on the Tibetan Plateau in China. Chinese Journal of Practical Internal Medicine, 32(5), 3.

[3] Wang, Yaping, & Geri. (2012). Advances in the study of altitude decline disorder. Chinese Medical Journal, 92(32), 3.

[4] Partridge B J, Bell S K, Lucke J C, et al. Smart Drugs "As Common As Coffee": Media Hype about Neuroenhancement[J]. Plos One, 2011, 6(11):e28416.

[5] Graf W D, Nagel S K, Epstein L G, et al. Pediatric neuroenhancement: ethical, legal, social, and neurodevelopmental implications[J]. Neurology, 2013, 80(13):1251-1260.

[6] Heinz A, Kipke R, S Müller, et al. True and false concerns about neuroenhancement: a response to 'Neuroenhancers, addiction and research ethics', by D M Shaw[J]. Journal of Medical Ethics, 2014, 40(4).

[7] Roland P E, Levin B, Kawashima R, et al. Three‐dimensional analysis of clustered voxels in 15 O‐butanol brain activation images[J]. Human Brain Mapping, 1993, 1(1):3–19.

[8] Ha ZD, Zhu JY, & Jane XL. (2015). Effects of different interventions on sleep sao2 in youth migrating to 5380m above sea level. Journal of Highland Medicine (4), 5.

[9] Xie S. W., Li W. J., Zhao H., & Wang T. H.. (2019). Effect of different oxygenation flow rates on postoperative oxygen saturation in patients at high altitude plateau. Surgical Theory and Practice (2), 4.

[10] Wang, Zhen. (2008). Oxygen therapy for patients with respiratory failure in pulmonary heart disease at high altitude. Chinese and Foreign Medical Science (16), 1.

[11] Duan, Jinqing, Liu, Zheng, & Liu, Hongbin. (2007). Comparison of the efficacy of hyperbaric oxygen and normobaric mask oxygenation in the treatment of acute mild plateau sickness. Chinese Journal of Marine Medicine and Hyperbaric Medicine, 14(3), 2.

[12] Chen, J., Zheng, B. H., Yan, Y. P., Li, S. H., Zheng, J. P., & Guo, J. et al. (2014). Effect of oxygen therapy on correlation of blood pressure changes in plateau at different altitudes. Proceedings of the 10th National Conference on Integrative Medicine and Disaster Medicine in Jiangsu Province, 2014.

[13] Barkley RA, Edwards G, Laneri M, Fletcher K, Metevia L (2001) cognitive functioning, temporal discounting, and sense of time in adolescents with attention deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). J A born Child Psychology 29:541–556.

[14] Yang GY, Feng ZZ, Wang T. Effects of altitude hypoxia on psychological function and protection [J]. Chinese Behavioral Medicine Science, 2003, 12(004): 471-3.

[15] Wang Hongyun, Cui Jianhua, Jin Xianghua. Research Progress on anti hypoxia effect of hyperbaric oxygen and prevention and treatment of altitude sickness [J]. Journal of high altitude medicine, 2009 (01): 58-61.

[16] Li Zhijing, Jin Xianglan. Research progress of oxygen therapy for acute ischemic stroke [J]. Medical review, 2020, v.26 (02): 104-108.

[17] Ma H-L, Zhang X-J, Yang Z-T. Effects of long-term high-altitude exposure on attention networks of migrants and sedentary residents [J]. Chinese Journal of Plateau Medicine and Biology, 2017, 38(004): P.267-72.

[18] Wang, Y., Ye, A., Peng, D., Miao, C., Di, Z., & Gong, W. (2022). Spatiotemporal variations in water conservation function of the Tibetan Plateau under climate change based on INVEST model. Journal of Hydrology: Regional Studies, 41, 101064.

[19] Glass, J. M., Buu, A., Adams, K. M., Nigg, J. T., & Zucker, R. A. (2010). Effects of alcoholism severity and smoking on cognitive neurocognitive function. Addiction, 104(1), 38-48.

[20] Peng Huiping, Lu Xiaoxin, Tang Yongjian, et al. Clinical application of atmospheric oxygen therapy [J]. Journal of Fuzhou General Hospital, 2005, 34 (003): 651-652.

[21] Lu Xiaoxin, Tang Yongjian, He Suyu. Effect of combined therapy of normobaric oxygen and hyperbaric oxygen on severe brain injury [J]. Chinese clinical rehabilitation, 2002.

[22] Li Guoqing, Meng ran, Ren Changhong, et al. Effects of intermittent normobaric hypoxia post adaptation on cerebral white matter injury and cognitive dysfunction in rats with chronic cerebral blood flow hypoperfusion [J]. Chinese Journal of geriatric cardiovascular and cerebrovascular diseases, 2013, 005 (005): 530-535.

[23] Bu, Xiao-Ou, Yang, Xiyue, Zhang, Delong, & Ma, Hailin. 2011 A new species of the genus Phyllostachys (Hymenoptera, Braconidae) from China. (2021). Single hyperbaric oxygen intervention improves attentional network in high-altitude transplants. Journal of Physiology.

[24] Yu Ning, Li Tong, Huang Qiliang, et al. Clinical study on the effect of early hyperbaric oxygen therapy on cerebral blood perfusion and prognosis in patients with acute cerebral infarction [J]. Stroke and neurological disease, 2013 (01): 43-45.

[25] Leckie R L, Oberlin L E, Voss M W, et al. BDNF mediates improvements in executive function following a 1-year exercise intervention[J]. Frontiers in Human Neuroscience, 2014, 8(985):985.

[26] Chen, F C, Wang, et al. Impact of acute aerobic exercise and cardiorespiratory fitness on visuospatial attention performance and serum BDNF levels[J]. Psychoneuroendocrinology: An International Journal, 2014, 41:121-131.

[27] Chung S C, Tack G R, Choi M H, et al. Changes in reaction time when using oxygen inhalation during simple visual matching tasks[J]. Neuroscience Letters, 2009, 453(3):175-177.

[28] Qin Jie, you Chunjing. Effect of hyperbaric oxygen on the number of choline acetyltransferase positive neurons in frontal cortex and hippocampus of rats with brain injury [J]. Chinese Journal of physical medicine and rehabilitation, 2006, 28 (5): 302-304.

[29] Leckie R L, Oberlin L E, Voss M W, et al. BDNF mediates improvements in executive function following a 1-year exercise intervention[J]. Frontiers in Human Neuroscience, 2014, 8(985):985.

[30] Gu binliang, Roger Effect of hyperbaric oxygen chamber combined with aerobic training on cognitive function of patients with moderate brain injury [J]. Chinese Journal of practical neurological diseases, 2017, 20 (023): 43-45.

[31] Tian Feng, Hu Lixun. Effects of aerobic exercise combined with hyperbaric oxygen on cognitive function, blood-brain barrier and oxygen free radicals in rats with global cerebral ischemia-reperfusion [J]. Chinese Journal of Nautical Medicine and high pressure medicine, 2018, 025 (002): 81-85.