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Frontiers in Medical Science Research, 2022, 4(13); doi: 10.25236/FMSR.2022.041308.

Research progress on the correlation between primary aldosteronism and bone metabolism


Yueyue Chai1, Rui Ma1, Yuting Shao1, Fuguang He2, Fuqiang Liu1, Hong Lai1

Corresponding Author:
Hong Lai

1Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

2Department of Internal Medicine, Shandong Pingyuan County Hospital of Traditional Chinese Medicine, Dezhou, Shandong, China


Primary aldosteronism is a clinical syndrome characterized by hypertension, with or without hypokalemia, low renin and hyperaldosteronism, which is a common endocrine hypertension due to adrenal cortical lesions and excessive autonomic aldosteronism, resulting in increased retention of sodium and potassium and volume load.  Studies have shown that aldosterone overdose increases the risk of cardiovascular disease, renal insufficiency, diabetes, metabolic syndrome and even death. In recent years, studies have pointed out that patients with primary aldosteronism have increased urinary calcium and elevated parathyroid hormone, and the prevalence of osteoporosis and fracture is higher than that of essential hypertension and healthy people. Primary aldosteronism may be a secondary cause of osteoporosis, but the specific pathogenesis remains unclear. This article reviews the correlation of bone metabolism and possible pathogenesis of primary aldosteronism.


primary aldosteronism; parathyroid hormone; osteoporosis; fracture

Cite This Paper

Yueyue Chai, Rui Ma, Yuting Shao, Fuguang He, Fuqiang Liu, Hong Lai. Research progress on the correlation between primary aldosteronism and bone metabolism. Frontiers in Medical Science Research (2022) Vol. 4, Issue 13: 46-51. https://doi.org/10.25236/FMSR.2022.041308.


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