Steroid-induced avascular necrosis of the femoral head is a common refractory chronic disease in orthopedics. In recent years, with the improvement of people's living standards, the harmfulness and prevention of this disease has gradually been paid attention to. Research on the treatment of steroid-induced necrosis of the femoral head in China is increasing and good efficacy has been achieved. Based on the literature research in recent years, this paper focuses on the etiology and pathogenesis of traditional Chinese medicine, the progress and mechanism of traditional Chinese medicine treatment, etc. This paper summarized and briefly analyzed the research status of steroid-related necrosis of femoral head in recent years, and prospected a more reasonable application of traditional Chinese medicine in the treatment of steroid-related necrosis of femoral head in the future, in order to provide reference for the further prevention and treatment of steroid-related necrosis of femoral head by traditional Chinese medicine.

Liu Tianpeng. Research progress in Chinese medicine treatment of hormonal femoral head necrosis. Frontiers in Medical Science Research (2022) Vol. 4, Issue 14: 43-48. https://doi.org/10.25236/FMSR.2022.041406.

[1] Wu X, Sun W, Tan M. Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head[J]. Biomed Res Int, 2019, 2019: 8140595.

[2] Yang Y, Xu ZA, Kaiser J., et al. Advances in the treatment of hormonal femoral head necrosis[J]. Journal of Clinical Military Medicine, 2015, 43(12): 1316-1319.

[3] Cao LZ, Zhang XG, Zhao XY, et al. Progress of research on the correlation between hormonal femoral head necrosis and OPG/RANK/RANKL system from the perspective of "deficiency"[J]. Chinese Journal of Traditional Chinese Medicine Information, 2017, 24(04): 123-126.

[4] Fan Z Q, Bai SC, Xu Q, et al. Oxidative Stress Induced Osteocyte Apoptosis in Steroid-Induced Femoral Head Necrosis[J]. Orthop Surg, 2021, 13(7): 2145-2152.

[5] Zuo RT, Guan JJ, Kang QL. Research progress in the treatment of hormonal femoral head necrosis[J]. International Journal of Orthopaedics, 2019, 40(03): 160-164.

[6] Zhou LX, Li ZM, Duan J, et al. Progress of blood activation method for the prevention and treatment of early hormonal femoral head necrosis[J]. Electronic Journal of Trauma and Emergency Medicine, 2015, 3(02): 1-5.

[7] Liu YX, Yang JG. Collation and analysis of medullary disease evidence based on ancient Chinese medical literature[J]. Chinese Journal of Basic Chinese Medicine, 2015, 21(04): 383-385.

[8] Li JL, Zhang WX, Guo CL, et al. Progress of research on the correlation between hormonal femoral head necrosis and OPG/RANK/RANKL signaling pathway from the perspective of "stasis"[J]. Journal of Liaoning University of Chinese Medicine, 2021, 23(03): 164-168.

[9] Cao CZ, Hou DC. Exploring the etiology and pathogenesis of hormonal femoral head necrosis from the theory of phlegm and stasis[J]. Journal of Liaoning University of Chinese Medicine, 2017, 19(09): 168-170.

[10] Wang S, Cao LZ, Song M, et al. Progress in the study of OPG/RANK/RANKL signaling regulatory mechanism in hormonal femoral head necrosis treated from phlegm[J]. Chinese Journal of Traditional Chinese Medicine Information, 2017, 24(10): 133-136.

[11] Liu XY, Cao LZ, Song M, et al. Overview of research on Chinese medicine for the prevention and treatment of hormonal femoral head necrosis[J]. Chinese Traditional Chinese Medicine Emergency, 2016, 25(08): 1561-1563.

[12] Zhang YW. Clinical study on the treatment of hormonal femoral head necrosis by combining blood and marrow tonifying soup with marrow core decompression[J]. Liaoning Journal of Traditional Chinese Medicine, 2014, 41(10): 2177-2179.

[13] Chen H, Du B, Liu Z, et al. Progress in the treatment of glucocorticoid-related femoral head necrosis with Epimedium[J]. Chinese Journal of Integrated Chinese and Western Medicine, 2021, 41(11): 1401-1408.

[14] Wen YY, Sun HANR, Jia YD, et al. Recent research advances in Chinese medicine for the prevention and treatment of hormonal femoral head necrosis[J]. Systematic Medicine, 2019, 4(02): 187-189.

[15] Ji ZH, Jia BS, Zhou LY, et al. Clinical study on the treatment of early hormonal femoral head necrosis by activating blood circulation, resolving blood stasis and promoting luo [J]. Chinese Pharmacology and Clinical Practice, 2017, 33(04): 178-181.

[16] Zhou ZX, Li WH, Zhu L, et al. Intervention of apoptosis in rabbits with hormonal femoral head necrosis model by Chinese herbal medicine Bone Palsy Tongxiao Granules[J]. Chinese Tissue Engineering Research, 2018, 22(20): 3190-3194.

[17] Zheng Y, Chen Z, Yin CD, et al. Professor Qiu Xiangzhong's experience in the treatment of non-traumatic femoral head necrosis in young adults based on the theory of "liver deficiency and ligament paralysis"[J]. Hebei Traditional Chinese Medicine, 2021, 43(06): 892-895.

[18] Wang JG, Fang JW, Yan XZ, et al. Study on the efficacy of Du Zhong tonifying kidney and bone building granules on hormonal ischemic necrosis of femoral head and the effects of serum PⅠNP, BGP, VEGF, TGF-β_1 and bone density[J]. China Medical Journal, 2017, 52(06): 36-39.

[19] Bai LC, He GY, Yao CF, et al. Experimental study on the effects of electroacupuncture on local tissue blood flow, osteocalcin and ultrastructure in rabbits with hormonal femoral head necrosis[J]. Chinese Journal of Traditional Chinese Medicine and Orthopaedics, 2011, 19(09): 1-3.

[20] Liu T. Experimental study on the intervention of topical bone pain cream in hormonal femoral head necrosis in rabbits[D]. Beijing University of Traditional Chinese Medicine, 2019.

[21] Li HT, Li YQ, Sun XW, et al. Effect of buried acupuncture combined with bone erosion capsules on serum OPG/RANKL expression in patients with early hormonal femoral head necrosis[J]. Clinical Journal of Acupuncture and Moxibustion, 2018, 34(08): 11-15.

[22] Wu HF, Wang J, Zhang B, et al. A preliminary exploration of Shi's injury experience in the treatment of hormonal femoral head necrosis[J]. Chinese Journal of Traditional Chinese Medicine, 2019, 34(08): 3541-3543. 

[23] Zhu SY, Ma SY,Yang K, et al. Clinical observation on the treatment of middle and late stage femoral head necrosis caused by hormones and alcohol with Tui Na plus Chinese herbal medicine[J]. Chinese Journal of Osteoporosis, 2015, 21(04): 456-459.

[24] Li ZY. Clinical study on the treatment of hormonal femoral head necrosis (bone erosion with phlegm and dampness) by combining the manual method with the addition and subtraction of warm gall bladder soup [D]. Changchun University of Traditional Chinese Medicine, 2021.

[25] Xue XH, Feng ZH, Li ZX, et al. Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies[J]. Mol Med Rep, 2018, 17(3): 3751-3757.

[26] Yu H. Chen. Experimental study on the intervention of Epimedium in bone microvascular endothelial cells to prevent hormonal femoral head necrosis[D]. Peking Union Medical College, 2020.

[27] Wei Q, He M, Chen M, et al. Icariin stimulates osteogenic differentiation of rat bone marrow stromal stem cells by increasing TAZ expression[J]. Biomed Pharmacother, 2017, 91: 581-589.

[28] Rui R. Experimental study on the regulation of OPG/RANK/RANKL system in the treatment of hormonal femoral head necrosis in mice with Bone Palsy Tongxiao Formula[D]. Anhui University of Traditional Chinese Medicine, 2020.

[29] Zhao DW, Yu M, Hu K, et al. Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey[J]. Chin Med J (Engl), 2015, 128(21): 2843-50.

[30] Al-Omari A A, Aleshawi A J, Marei O A, et al. Avascular necrosis of the femoral head after single steroid intra-articular injection[J]. Eur J Orthop Surg Traumatol, 2020, 30(2): 193-197.

[31] Chang C, Greenspan A, Gershwin M E. The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis[J]. J Autoimmun, 2020, 110: 102460.

[32] Kompel A J, Roemer F W, Murakami A M, et al. Intra-articular Corticosteroid Injections in the Hip and Knee: Perhaps Not as Safe as We Thought?[J]. Radiology, 2019, 293(3): 656-663.

[33] Li F, Li SH, Zhou MW, et al. Exploration of the Chinese medical theory on the pathogenesis of hormonal femoral head necrosis and the current status of research on Chinese medicine constitution[J]. Western Traditional Chinese Medicine, 2018, 31(02): 135-137.