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Frontiers in Medical Science Research, 2022, 4(14); doi: 10.25236/FMSR.2022.041408.

A model organism for studying aging genes under lipid peroxidation


Chung-Hsing Chao

Corresponding Author:
Chung-Hsing Chao

Department of Intelligent Vehicles and Energy, Minth University of Science and Technology, Hsinchu, Taiwan


A study conducted in this paper examines the relationship between hydrogen peroxide accumulation caused by the nematode aging gene daf-16 and accelerated metabolic rate caused by the nucleolar regulatory gene ncl-1. The daf-16 mutant and wild-type nematodes (called N2) were obtained and their ncl-1 gene was blocked by RNAi technology to understand nucleolar formation, growth cycle, and longevity. Nucleus appears early if ncl-1 is blocked, regardless of whether daf-16 is present. There is an additive effect between these two genes on nematode longevity. Among the wild-type nematodes, n2 had the longest lifespan, while the double-mutant nematodes, daf-16 and ncl-1, had the shortest. A nematode's lifespan is markedly reduced when the two genes do not express at the same time. This shows that a single mutation causes the lifespan of the nematode to decrease by approximately the same amount when daf-16 or ncl-1 are not expressed.


Modal organisms, Nematodes, Aging gene, Nucleolus

Cite This Paper

Chung-Hsing Chao. A model organism for studying aging genes under lipid peroxidation. Frontiers in Medical Science Research (2022) Vol. 4, Issue 14: 55-59. https://doi.org/10.25236/FMSR.2022.041408.


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