Frontiers in Medical Science Research, 2019, 1(3); doi: 10.25236/FMSR.2019.010301.
Hui Yang¹, Yang Dezhen², Feng Feixue², Hou Junming²
1.Shaanxi University of Chinese Medicine, Shaanxi, Xi-Xian District 712046,China
2.Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi, Xianyang 712000,China
In recent years, traditional Chinese medicine (TCM) has been widely used in the treatment and rehabilitation of cancer patients, all of which benefit from its prominent efficacy of synergy and detoxification. TCM holds that when blood meets heat coagulation, burning is phlegm,phlegm, turbidity, Qi and blood can block meridians and viscera, coalesce into tumors. It can be seen that one of the most important causes leading to tumors is heat toxicity. Although the method of clearing away heat and detoxification belongs to the treatment of attacking pathogens, it also has a wide range of regulating effects on the body, making it different from the pure drug of attacking pathogens. Therefore, the author reviews the general treatment of cancer patients by prescriptions, drugs and active ingredients with heat-clearing and detoxifying effects, as well as the mechanism of influencing the metabolism of cancer cells and enhancing the immunity of the body. It is concluded that Qingre Jiedu recipe can not only promote the apoptosis of tumor cells, inhibit the proliferation and invasion of tumors, but also have significant effects in regulating immune anti-tumor and multi-drug resistance.
Heat-Clearing And Detoxification; Traditional Chinese Medicine; Anti-Cancer; Mechanism Of Action; Review
Hui Yang, Yang Dezhen, Feng Feixue, Hou Junming. Research methods and evaluation of antipyretic prescriptions. Frontiers in Medical Science Research (2019) Vol. 1 Issue 3: 1-6. https://doi.org/10.25236/FMSR.2019.010301.
[1]D.Meng(2017).Heat Toxicity and Research Progress of Gastrointestinal Cancer Mengdan. Global Traditional Chinese Medicine, vol. 10, no.6, p.768-772.
[2]J.Z. Ren(2019). Exploring the anti-tumor mechanism of Baitouweng Decoction based on network pharmacology.World Clinical Drugs. vol. 40, no.4, p.241-248.
[3]J.M. Hou (2016). Ehuang Decoction retention enema on growth and expression of vascular endothelial growth factor of human colon cancer SW480 transplanted tumor. Shaanxi Traditional Chinese Medicine, vol.37, no.9, p.1264-1266.
[4]T. Yang (2102). Effect of Rhubarb Extract on Hepatic Stellate Cell Apoptosis. The 21st National Conference on Integrated Traditional Chinese and Western Medicine Liver Diseases, vol.1, p.127-136.
[5]Z.Zhou(2019). Baicalein enhances apoptotic effect of arsenic trioxide on hepatocellular carcinoma cells through PI3K/AKT pathway. Modern oncology medicine,vol.27, no.10, p.1661-1668.
[6]S. Li (2010).The effect and mechanism of Zhonglou extract on the proliferation of human colon cancer SW480 cells. Chinese Journal of Biological Products,vol.23, no.6, p.619-622,632.
[7]B.Y.Chen(2017).Advances in Anti-Tumor Effects and Mechanisms of Andrographolide. Chinese New Clinical Medicine.vol.10,no.7, p.695-698.
[8]Y. Liu (2010). Effects of Hedyotis diffusa on the activity of omission-enzyme and hTERT gene expression in human cervical cancer Hela cells. Tumor basis and clinical, vol.23, no.2, p.103-106.
[9]C. Gao(2010).The effect of Hedyotis diffusa on Hela cell cycle apoptosis and Telomerase activity. Journal of Xuzhou Medical College, vol.30, no.7, p.466-468.
[10]P.C.Lu(1989).Regulation of Scutellaria barbata polysaccharide on cellular immunity. Journal of Nanjing College of Traditional Chinese Medicine,vol.2, no. 2, p.32-33,39.
[11]H.Q. Wang (2006).Effects of Chinese herbs for clearing away heat, detoxifying and tonifying toxins on mouse ascites hepatocellular carcinoma ellipsis 22 cells and comparison of immunological mechanisms.Journal of Guangzhou University of Traditional Chinese Medicine, vol.23, no.2, p.156-159.
[12]Y.X.Yu (2007).Shikonin reverses the expression of JAR_MTX_ellipsis_ivin and Bcl_2 in choriocarcinoma cells. Journal of Third Military Medical University, vol.29, no.19, p.1880-1882.
[13]H.Y.Li(2014). Shikonin-induced expression of Calreticulin in ovarian cancer cells to promote DC maturation. Modern Journal of Integrated Traditional Chinese and Western Medicine, vol.23, no.5, p.472-476,486.
[14]Q.Zhang (2019).Advances in Anti-Tumor Effects of Astragaloside. Information on Traditional Chinese Medicine, vol.36, no.1, p.129-132.