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Frontiers in Medical Science Research, 2022, 4(15); doi: 10.25236/FMSR.2022.041509.

Original article of prevalence, risk factors and clinical characteristics of constipation in Chinese patients with schizophrenia


Yan Kong1, Jianjun Hu1, Xirong Sun1, Haiying Min1, Ling Wang1, Jie Yuan1, Jiechun Zhang1, Xiangyang Zhang2,3

Corresponding Author:
Jianjun Hu

1Clinical Research Center for Mental Illness of Tongji University, Shanghai Pudong New Area Mental Health Center and Affiliated Mental Health Center of Tongji University, Shanghai, China

2CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China

3Department of Psychology, University of Chinese Academy of Sciences, Beijing, China


Background: The aim of study was to explore the prevalence and clinical characteristics of constipation in Chinese inpatients with schizophrenia and analyze its risk factors. Methods: 806 schizophrenic patients in Shanghai were recruited to analyze the prevalence of constipation and the clinical characteristics of schizophrenic patients. According to whether the patients had constipation, they were divided into constipation group and normal group. The living conditions of the two groups were compared, and the risk factors of constipation were analyzed. Finally, the ROC curve was used to determine the predictive efficacy of the related factors on constipation, and the utilization of the risk factors Logistic regression analysis was used to determine the important factors of constipation. Results: The prevalence of constipation in Chinese schizophrenic patients was higher than that in the general population. The prevalence of mild constipation was 32.5% in 806 schizophrenic patients, and the prevalence of severe constipation was 20.9%. There was also gender difference in the prevalence of constipation in schizophrenic patients, among which the prevalence of female constipation was 17.6%, and that of male constipation was 9.9%. The dietary habits of patients also had a significant impact on the prevalence of constipation (P=0.001). Conclusion: The risk of constipation in female patients with schizophrenia is significantly higher than that in male patients. The incidence of constipation is related to gender, age, education level, negative symptoms, PANSS total score, smoking, exercise and drinking water. Gender, education level and daily smoking are important predictors of constipation.


China; schizophrenia; risk factors; regression analysis

Cite This Paper

Yan Kong, Jianjun Hu, Xirong Sun, Haiying Min, Ling Wang, JieYuan, Jiechun Zhang, Xiangyang Zhang. Original article of prevalence, risk factors and clinical characteristics of constipation in Chinese patients with schizophrenia. Frontiers in Medical Science Research (2022) Vol. 4, Issue 15: 55-64. https://doi.org/10.25236/FMSR.2022.041509.


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