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Academic Journal of Engineering and Technology Science, 2019, 2(4); doi: 10.25236/AJETS.2019.020402.

Study on Hydrolysis of Icariin Glycoside to Anhydroicaritin

Author(s)

Jiaqiang Yang*, Silan Liu

Corresponding Author:
Jiaqiang Yang
Affiliation(s)

School of Pharmacy, Zunyi Medical University, Zunyi 563000, China
*Corresponding author e-mail: yjqzmc@163.com

Abstract

In order to optimize the preparation process of icariin, the method of hydrolyzing icariin was used to prepare icariin. The effects of acid type, solvent concentration, reaction temperature and reaction time on the yield were investigated. The optimum preparation conditions were obtained, under the action of concentrated sulfuric acid, 90% ethanol was used as solvent, and the reaction temperature was 80℃ for 3 hours.

Keywords

Icariin glycoside, hydrolysis, anhydroicaritin

Cite This Paper

Jiaqiang Yang, Silan Liu. Study on Hydrolysis of Icariin Glycoside to Anhydroicaritin. Academic Journal of Engineering and Technology Science (2019) Vol. 2 Issue 4: 6-11. https://doi.org/10.25236/AJETS.2019.020402.

References

[1] H.P. Ma, X.R. He, Y. Yang, et al. The genus Epimedium: an ethnopharmacological and phytochemical review. Journal of Ethnopharmacology, vol.134, no.3, p.519-541.
[2] Z.G. Zheng, X. Zhang, Y.P. Zhou, et al. Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice. European Journal of Pharmacology, vol.809, p.156-162.
[3] M.L. Nan, S.C. Li, Y.W. Zhao, et al. Preparation method and pharmacological activity of anhydroicaritin. Chinese Journal of Experimental Traditional Medical Formulae, vol.21, no.7, p.227-231.
[4] J. Huang, L. Yuan, X. Wang, et al. Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro. Life Sciences, vol.81, no.10, p.832-840.
[5] S. Li, M.H. Pan, C.S. Lai, et al. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic and Medicinal Chemistry, vol.15, no.10, p.3381-3389.
[6] J.Y. Zhu, X.L. Li. Study on acid hydrolysis condition of icariin glycoside. Studies of Trace Elements and Health, vol.27, no.3, p.49-51.
[7] Y.P. Li, X.H. Zhang, H. Peng, et al. Effects of anhydroicaritin and 2"-hydroxy-3"-en- anhydroicaritin on the proliferation and differentiation of MC3T3-E1 osteoblasts. Natural Product Communications, vol.7, no.11, p.1461-1464.
[8] V.S. Nguyen, Shi L, S.C. Wang, et al. Synthesis of icaritin and β-anhydroicaritin Mannich base derivatives and their cytotoxic activities on three human cancer cell lines. Anti-Cancer Agents in Medicinal Chemistry, vol.17, no.1, p.137-142.