Solitary pulmonary nodule (SPN) is a common imaging manifestation in clinic, which is usually found accidentally during routine physical examination or routine chest imaging examination in hospital due to other diseases. Solitary pulmonary nodules can be either benign or malignant, and the clinical treatment is different for different natures. Therefore, how to evaluate and accurately judge the nature of solitary pulmonary nodules is particularly important for the selection of treatment. This article reviews the literature on evaluation strategies, imaging diagnosis methods and treatment methods of solitary pulmonary nodules in recent years, and summarizes them as follows.

Lingling Fu. Core exploration of progress in diagnosis and treatment of solitary pulmonary nodules. Frontiers in Medical Science Research (2023) Vol. 5, Issue 1: 32-36. https://doi.org/10.25236/FMSR.2023.050106.

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[2] Jokerst C, Adler C, Gotway M, et al. Dual Energy Technique Adds Value to Solitary Pulmonary Nodule Analysis with Dynamic Contrast-Enhanced CT: A 100 Nodule Experience. Curr Probl Diagn Radiol, 2023,52(1):25-30.

[3] Wang Yubo, Cao Guoqiang. Early diagnosis of isolated pulmonary nodules. Journal of Clinical Pulmonary Science, 2012,17 (7): 1302-1303.

[4]Liu Jilu, On the diagnosis of isolated nodules in the lungs. Guidelines for Health care, 2017, (2): 218.

[5] Chen Ming, CT diagnosis and differential diagnosis of solitary nodules in the lungs. The World's Latest Medical Information Abstract (Continuous Electronic Journal), 2019,19 (51): 172,175.

[6] Gu Mingzhong, Chen Jinbei, Wang Wencai, Qiu Aimin. Lung primary isolated small nodules of 62 cases of clinical analysis. Sichuan Medicine, 2008,29 (11): 1546-1547.

[7] Duke JD, Fernandez-Bussy S, Reisenauer J. Combined portable cone beam computed tomography and robotic-assisted bronchoscopy impacting diagnosis of a solitary pulmonary nodule: a case report. AME Case Rep, 2022,6:23.

[8] Yuan CT, Chen JS, Huang YL, et al. ALK-positive histiocytosis presenting as a solitary pulmonary nodule. Br J Haematol, 2022, 199(1):7.

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[10] Jiang Xinhua and Yu Dongping. Current status and progress of perfusion imaging of isolated pulmonary nodules. Jiangxi Medicine, 2011,46 (7): 670-673.

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[13] Zhuo Y, Zhan Y, Zhang Z, et al. Clinical and CT Radiomics Nomogram for Preoperative Differentiation of Pulmonary Adenocarcinoma From Tuberculoma in Solitary Solid Nodule. Front Oncol, 2021,11:701598.

[14] Jiang Yifei. Clinical analysis of 42 cases of peripheral pulmonary solitary nodules with CT-guided percutaneous lung puncture biopsy. 2005.

[15] Huang Feng, Chen Xiaoqi, Qi Le. Clinical study on the size of solitary pulmonary nodules and puncture biopsy. Journal of Clinical Medicine, 2006,(10):1023-1024. 

[16] Shangang L, Chengli L, Xuejuan Y, et al. Diagnostic accuracy of MRI-guided percutaneous transthoracic needle biopsy of solitary pulmonary nodules. Cardiovasc Intervent Radiol, 2015,38(2).

[17] Govindraj R, Chowdhry F, Ang K, et al. Intra-operative frozen section diagnosis of the suspicious solitary pulmonary nodule, how can we improve the strike-rate. J Cardiothorac Surg, 2013,8(1suppl).

[18] Li H, Zou J, Li J. Organizing pneumonia with solitary focal nodule and subsequent multiple pulmonary shadows. Am J Med Sci, 2022,364(1):e4-e5.

[19] Cong CV, Luong DV, Anh TT, et al. Pulmonary arteriovenous malformation and inherent complications with solitary lung nodule biopsy-literature overview and case report. Radiol Case Rep, 2022,17(7):2353-2361.

[20] Ko JP, Bagga B, Gozansky E, et al. Solitary Pulmonary Nodule Evaluation: Pearls and Pitfalls. Semin Ultrasound CT MR, 2022,43(3):230-245.

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