Objective: A systematic assessment of taijiquan fitness effects from an immunological perspective, with the aid of bioinformatics analysis. Methods: Bioinformatics as a means of analysis, including mainly: Gene Set Enrichment Analysis (GSEA analysis), GO pathway enrichment and PPI network integration to systematically analyse the target data sources (RNA-Seq data from Parkinson's patient population after 12 weeks of TCC and MET exercise) in the GEO database; Results: The TCC group significantly increased the expression of primary T cells relative to the MET group; it effectively increased the number of human CD8+ T and NK cells. human neutrophils were highly expressed in the MET group; TCC may activate more T cells, especially CD8+ and NK cells, by activating aerobic metabolic pathways in the body, whereas MET activates the expression of neutrophils and monocytes. TCC movement enhances the function of mitochondria in immune cells through respiration, which in turn further activates T cell proliferation through epigenetic modifications that move. Conclusion: TCC exercise is effective in boosting the body's acquired adaptive immunity, while MET exercise stimulates the activity of the body's innate immunity, making TCC more suitable for health and wellness, especially for the chronic patient population.

Weimin Chen, Zhejian Wu, Xiaowen Zhang, Yiqing Guan, Wang Fei. Bioinformatics analysis based on the fitness effects of taijiquan in human immunity. Frontiers in Medical Science Research (2023) Vol. 5, Issue 1: 47-54. https://doi.org/10.25236/FMSR.2023.050109.

[1] Tan YT, Gao YT, Liu DK et al.  Physical activity patterns of middle-aged and elderly women in Shanghai[J]. Chinese Chronic Disease Prevention and Control, 2007, 15(4): 309-313.

[2] Wang C, Collet JP, Lau J: The effect of TCC exercise on health outcomes in patients with chronic conditions: a systematic review. Arch Intern Med 164:493– 501, 2004

[3] Lu WA, Kuo CD: The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sports Exerc 35:1972–1976, 2003 

[4] Tsang WW, Hui-Chan CW: Effect of 4- and 8-wk intensive Tai Chi training on balance control in the elderly. Med Sci Sports Exerc 36:648 – 657, 2004 

[5] Yeh SH, Chuang H, Lin LW, Hsiao CY, Eng HL: Regular Tai Chi Chuan exercise enhances functional mobility and CD4CD25 regulatory T cells. Br J Sports Med 40:239 –243, 2006

[6] Bruunsgaard H: Physical activity and modulation of systemic low-level inflamation. J Leukoc Biol 78:819 – 835, 2005 

[7] Peterson AM, Pederson BK: The antiinflammatory effect of exercise. J ApplPhysiol 98:1154 –1162, 2005 

[8] Suzuki K, Nakaji S, Yamada M, Liu Q, Kurakake S, Okamura N, Kumae T, Umeda T, Sugawara K: Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc 35:348 –355, 2003 

[9] Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K: Systemic inflflammatory response to exhaustive exercise: cytokine kinetics. Exerc Immunol Rev 8:6 – 48, 2002 

[10] Nieman DC: Current perspective on exercise immunology. Curr Sports Med Rep 2:239 –242, 2003 

[11] Shore S, Shinkai S, Rhind S, Shephard RJ: Immune responses to training: how critical is training volume? J Sports Med Phys Fitness 39:1–11, 1999 

[12] Davis JM, Murphy EA, Brown AS, Carmichael MD, Ghaffar A, Mayer EP: Effects of moderate exercise and oat beta-glucan on innate immune function and susceptibility to respiratory infection. Am J Physiol Regul Integr Comp Physiol 286:R366 – R372, 2004 

[13] Shore S, Shinkai S, Rhind S, et al. Immune responses to training: how critical is training volume? J Sports Med Phys Fitness 1999;39:1–11.

[14] An Nan, Wang Songtao, Wang Anli et al.  Research on the appropriate intensity of fitness exercise for middle-aged and elderly women[J].  Sports Science. 2005, 25(8): 62-66.

[15] Wang C, Collet JP, Lau J. The effect of TCC exercise on health outcomes in patients with chronic conditions: a systematic review. Arch Intern Med 2004;164:493–501.

[16] Chan SP, Luk TC, Hong Y. Kinematic and electromyographic analysis of the push movement in tai chi. Br J Sports Med 2003;37:339–44. 

[17] Li JX, Hong Y, Chan KM. Tai chi: physiological characteristics and beneficial effects on health. Br J Sports Med 2001;35:148–56. 

[18] Li JX, Hong Y, Chan KM. Effects of long term Tai Chi practice and jogging exercise on muscle strength and endurance in older people. Br J Sports Med 2006;40:50–4.

[19] McCarthy, D. A. and Dale, M. M. (1988) ‘The leucocytosis of exercise. A review and model.’, Sports medicine (Auckland, N.Z.). New Zealand, 6(6), pp. 333–363. 

[20] McCarthy and Dale, 1988;Kappel, M. et al. (1993) ‘Effects of an Acute Bolus Growth Hormone Infusion on the Human Immune System’, Horm Metab Res, 25(11), pp. 579–585. doi: 10. 1055/s-2007-1002181., 1993

[21] Pyne, D. (1994) ‘Regulation of neutrophil function during exercise.’, Sports medicine (Auckland, N.Z.), 17(4), pp. 245–58. doi: 10.2165/00007256-199417040-00005.

[22] Summers, C. et al. (2010) ‘Neutrophil kinetics in health and disease’, Trends in Immunology. Elsevier Science Ltd, 31(8), pp. 318–324. doi: 10.1016/j.it.2010.05.006.

[23] Brown, W. M. C. et al. (2015) ‘A Systematic Review of the Acute Effects of Exercise on Immune and Inflammatory Indices in Untrained Adults’, Sports Medicine - Open. Sports Medicine - Open, 1(1), p. 35. doi: 10.1186/s40798-015-0032-x.

[24] Pyne, D. (1994) ‘Regulation of neutrophil function during exercise.’, Sports medicine (Auckland, N.Z.), 17(4), pp. 245–58. doi: 10.2165/00007256-199417040-00005.

[25] Mooren, F. C. et al. (2012) ‘Exercise delays neutrophil apoptosis by a G-CSF-dependent mechanism’, Journal of Applied Physiology, 113(7), pp. 1082–1090. doi: 10. 1152/ japplphysiol. 00797. 2012.

[26] Pyne, 1994;Pyne, D. B. et al. (1995) ‘Effects of an intensive 12-wk training program by elite swimmers on neutrophil oxidative activity.’, Medicine and science in sports and exercise. United States.

[27] Su, S. H., Jen, C. J. and Chen, H. ing (2011) ‘NO signaling in exercise training-induced antiapoptotic effects in human neutrophils’, Biochemical and Biophysical Research Communications. Elsevier Inc., 405(1), pp. 58–63. doi:10.1016/j.bbrc.2010.12.123.

[28] Syu, G. Da, Chen, H. I. and Jen, C. J. (2011) ‘Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status’, PLoS ONE, 6(9). doi: 10. 1371/ journal. pone.0024385.

[29] Emmons, R. et al. (2016) ‘Acute exercise mobilizes hematopoietic stem and progenitor cells and alters the mesenchymal stromal cell secretome’, Journal of Applied Physiology, 120(6), pp. 624–632. doi: 10.1152/japplphysiol.00925.2015.