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Frontiers in Medical Science Research, 2023, 5(1); doi: 10.25236/FMSR.2023.050112.

Research on the clinical treatment of hypertriglyceridemia and acute pancreatitis

Author(s)

Biao Tan, Yi Hu

Corresponding Author:
Yi Hu
Affiliation(s)

Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China

Abstract

Hypertriglyceridemia is the third most common cause of acute pancreatitis in the world [1]. In China, hypertriglyceridemia is gradually rising as the second leading cause of acute pancreatitis [2]. The disease usually occurs in patients with an underlying disorder of lipoprotein metabolisms and secondary conditions such as poorly controlled diabetes mellitus, alcohol abuse, or particular drug use. The clinical manifestations of pancreatitis caused by hypertriglyceridemia are generally similar to acute pancreatitis caused by other causes. However, patients with pancreatitis caused by hypertriglyceridemia may have a longer course of the disease and more complications [3], accompanied by a higher possibility of persistent organ failure. The initial treatment of pancreatitis due to hypertriglyceridemia is similar to that of acute pancreatitis from other causes. It includes aggressive fluid resuscitation, pain control, and nutritional support. In acute pancreatitis, timely recognition of hypertriglyceridemia is crucial in the initial and long-term management of the disease. It is also critical for preventing the recurrence of acute pancreatitis.

Keywords

hypertriglyceridemia; acute pancreatitis; pathogenesis; prognosis

Cite This Paper

Biao Tan, Yi Hu. Research on the clinical treatment of hypertriglyceridemia and acute pancreatitis. Frontiers in Medical Science Research (2023) Vol. 5, Issue 1: 65-68. https://doi.org/10.25236/FMSR.2023.050112.

References

[1] Jin, M., et al., A 16-year trend of etiology in acute pancreatitis: The increasing proportion of hypertriglyceridemia-associated acute pancreatitis and its adverse effect on prognosis. J Clin Lipidol, 2019. 

[2] Sun Ya Mei,Gao Feng,Chen Xue et al. The relationship between triglyceride level and the severity of acute hypertriglyceridemic pancreatitis in Chinese patients. Turk J Gastroenterol, 2020, 31: 633-639.

[3] Li, Q., et al., Diabetes and Younger Age Are Vital and Independent Risk Factors for Acute Pancreatitis in Patients with Severe Hypertriglyceridemia. Biomed Res Int, 2019. 2019: p.2620750. 

[4] Munoz Michael A, Sathyakumar Kaviya, Babu Benson A, Acute pancreatitis secondary to hypertriglyceridemia. Cleve Clin J Med, 2020, 87: 742-750.

[5] Papachristou, G.I., et al., Acute pancreatitis patient registry to examine novel therapies in clinical experience (APPRENTICE): an international, multicenter consortium for the study of acute pancreatitis. Ann Gastroenterol, 2017. 30(1): p. 106-113.

[6] Zheng C B, Zheng Z H,Zheng Y P. Therapeutic plasma exchange for hyperlipidemic pancreatitis: Current evidence and unmet needs. World J Clin Cases, 2021. 9: 5794-5803. 

[7] Li, Q., et al., Diabetes and Younger Age Are Vital and Independent Risk Factors for Acute Pancreatitis in Patients with Severe Hypertriglyceridemia. Biomed Res Int, 2019. 2019: p. 2620750.

[8] Wang L, Xu T, Wang R, et al. Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research. Dig Dis Sci, 2021.

[9] Carr Rosalie A, Rejowski Benjamin J, Cote Gregory A et al. Systematic review of hypertriglyceridemia-induced acute pancreatitis: A more virulent etiology? .Pancreatology, 2016, 16: 469-76.

[10] Rhmari Tlemçani Fatima Zahra, Delsa Hanane, Elamari Saloua et al. Diabetic Ketoacidosis With Acute Metabolic Pancreatitis: Two Serious Cases. Cureus, 2022, 14: e20987.

[11] Lu Zhihua, Zhang Ge, Guo Feng et al. Elevated triglycerides on admission positively correlate with the severity of hypertriglyceridaemic pancreatitis. Int J Clin Pract, 2020, 74: e13458.

[12] Zafrir Barak, Saliba Walid, Jubran Ayman et al. Severe Hypertriglyceridemia-Related Pancreatitis: Characteristics and Predictors of Recurrence. Pancreas, 2019, 48: 182-186.

[13] Hegele RA, Ginsberg HN, Chapman MJ, et al. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014; 2: 655–666.

[14] Simha Vinaya, Management of hypertriglyceridemia. BMJ, 2020, 371: m3109.

[15] Amblee A, Mohananey D, Morkos M, et al. Acute pancreatitis in patients with severe hypertriglyceridemia in a multiethnic minority population. Endocr Pract. 2018; 24: 429–436. 

[16] Tenner S, Baillie J, DeWitt J, et al. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013;108: 1400–15 (1416).

[17] Zarnescu NO, Barbu ST, Zarnescu Vasiliu EC, et al. Management of acute pancreatitis in the early stage. Maedica. 2015;10: 257–63.

[18] Rawla Prashanth, Sunkara Tagore, Thandra Krishna Chaitanya et al. Hypertriglyceridemia-induced pancreatitis: updated review of current treatment and preventive strategies. Clin J Gastroenterol, 2018, 11: 441-448.

[19] Kuchay MS, Farooqui KJ, Bano T, et al. Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review. Arch Endocrinol Metab. 2017; 61: 198–201.

[20] He WH, Yu M, Zhu Y, et al. Emergent triglyceride-lowering therapy with early high-volume hemofiltration against low-molecularweight heparin combined with insulin in hypertriglyceridemic pancreatitis: a prospective randomized controlled trial. J Clin Gastroenterol. 2016; 50: 772–8. 

[21] Miyamoto K, Horibe M, Sanui M, et al. Plasmapheresis therapy has no triglyceride-lowering effect in patients with hypertriglyceridemic pancreatitis. Intensive Care Med. 2017; 43: 949–51.

[22] Scherer J, Singh VP, Pitchumoni CS, et al. Issues in hypertriglyceridemic pancreatitis: an update. J Clin Gastroenterol. 2014; 48: 195–203.